SCHEMBL290549

SCHEMBL290549

O=C(c1ccccc1)c1ccccc1N[C@@H](Cc1ccc(O)cc1)C(=O)O

nearest known ligand 0.76

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
PPARG P37231 20/20 0.76
PPARA Q07869 1/20 0.63

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2217249 1.00 PPARG (0.76) PPARGPPARA
SCHEMBL28214088 0.93 PPARG (0.66) PPARGPPARA
SCHEMBL9751930 0.92 PPARG (0.79) PPARGPPARA
SCHEMBL4156967 0.88 PPARG (0.61) PPARGPPARA
SCHEMBL1719719 0.88 PPARG (0.61) PPARGPPARA
SCHEMBL1749468 0.88 PPARG (0.61) PPARGPPARA
SCHEMBL27413268 0.87 PPARG (0.59) PPARGPPARA
SCHEMBL8335329 0.86 PPARG (0.72) PPARGPPARA
SCHEMBL11878375 0.86 PPARG (0.61) PPARG
SCHEMBL2785014 0.86 PPARG (0.88) PPARGPPARA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 401 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20140142145-A1 COMBINATIONS COMPRISING A DIPEPTIDYLPEPTIDASE - IV INHIBITOR BALKAN BORK (US) 2014-05-22 US claimed
US-7368286-B2 Method and device for identifying substances capable of modulating adipocyte differentiation GENFIT (FR) 2008-05-06 US claimed
US-20080076811-A1 COMBINATIONS COMPRISING DEPEPTIDYPEPTIDASE-IV INHIBITORS AND ANTIDIABETIC AGENTS BALKAN BORK 2008-03-27 US claimed
EP-1390026-A4 TREATMENT OF HPV CAUSED DISEASES CORNELL RES FOUNDATION INC (US) 2006-02-22 EP claimed
US-20050032064-A1 Method and device for identifying substances capable of modulating adipocyte differentiation GENFIT (FR) 2005-02-10 US claimed
EP-1468078-A1 METHOD AND DEVICE FOR IDENTIFYING SUBSTANCES CAPABLE OF MODULATING ADIPOCYTE DIFFERENTIATION Genfit (FR) 2004-10-20 EP claimed
US-20040171692-A1 Modulation of bone formation ANDREW SCUTT (GB) 2004-09-02 US claimed
EP-1390026-A1 TREATMENT OF HPV CAUSED DISEASES CORNELL RESEARCH FOUNDATION, INC. (US) 2004-02-25 EP claimed
JP-2003522787-A 2003-07-29 JP claimed
US-20030139372-A1 Modulation of bone formation UNIVERSITY OF SHEFFIELD (GB) 2003-07-24 US claimed
WO-2003060106-A1 METHOD AND DEVICE FOR IDENTIFYING SUBSTANCES CAPABLE OF MODULATING ADIPOCYTE DIFFERENTIATION GENFIT (FR) 2003-07-24 WO claimed
EP-1259233-A1 MODULATION OF BONE FORMATION THE UNIVERSITY OF SHEFFIELD (GB) 2002-11-27 EP claimed
WO-2002089790-A1 TREATMENT OF HPV CAUSED DISEASES CORNELL RESEARCH FOUNDATION, INC. (US) 2002-11-14 WO claimed
US-20020164385-A1 Treatment of HPV caused diseases CORNELL RESEARCH FOUNDATION, INC. 2002-11-07 US claimed
US-20020019344-A1 Methods of preventing allograft rejection PERSHADSINGH HARRIHAR A (US) 2002-02-14 US claimed
US-6316465-B1 Ophthalmic uses of PPARgamma agonists and PPARgamma antagonists PHOTOGENESIS, INC. 2001-11-13 US claimed
WO-2001060355-A1 MODULATION OF BONE FORMATION UNIVERSITY OF SHEFFIELD (GB) 2001-08-23 WO claimed
WO-2000000194-A1 OPHTHALMIC USES OF PPARGAMMA AGONISTS AND PPARGAMMA ANTAGONISTS PHOTOGENESIS, INC. (US) 2000-01-06 WO claimed
EP-1931350-B2 ADMINISTRATION OF DIPEPTIDYL PEPTIDASE INHIBITORS TAKEDA PHARMACEUTICALS CO (JP) 2021-08-04 EP disclosed
WO-1997031907-A1 SUBSTITUTED 4-HYDROXY-PHENYLALCANOIC ACID DERIVATIVES WITH AGONIST ACTIVITY TO PPAR-GAMMA GLAXO GROUP LIMITED (GB) 1997-09-04 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20080076811-A1 COMBINATIONS COMPRISING DEPEPTIDYPEPTIDASE-IV INHIBITORS AND ANTIDIABETIC AGENTS G6PC1, GCK, PDK4 PPARG 78/4885PPARA 554/4885
US-20020164385-A1 Treatment of HPV caused diseases PPARD, PPARG, PPARA PPARG 2/4885PPARA 3/4885
US-20140142145-A1 COMBINATIONS COMPRISING A DIPEPTIDYLPEPTIDASE - IV INHIBITOR DPP4, DPP7, DPP3 PPARG 695/4885PPARA 1446/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.