Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 5/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.53 |
| ▸ | ATM | Q13315 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 4/20 | 0.51 |
| ▸ | TP53 | P04637 | 3/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.48 |
| ▸ | THRB | P10828 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | HTT | P42858 | 2/20 | 0.46 |
| ▸ | PPARG | P37231 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29059242 | 0.89 | MEN1 (0.63) | MEN1KMT2AATMMAPTTP53 | |
| SCHEMBL29059145 | 0.88 | MEN1 (0.58) | MEN1KMT2AMAPTSMN1; SMN2KDM4E | |
| SCHEMBL29059274 | 0.87 | KMT2A (0.60) | MEN1KMT2AMAPTSMN1; SMN2KDM4E | |
| SCHEMBL29059392 | 0.79 | MEN1 (0.48) | MEN1KMT2AATMMAPTTP53 | |
| SCHEMBL29059139 | 0.78 | MEN1 (0.55) | MEN1KMT2AATMMAPTTP53 | |
| SCHEMBL29059277 | 0.78 | KDM4E (0.76) | MEN1KMT2AMAPTTP53SMN1; SMN2 | |
| SCHEMBL333940 | 0.78 | PTGES (0.44) | MEN1KMT2AATMMAPTTP53 | |
| SCHEMBL4223256 | 0.78 | PTGES (0.46) | MEN1KMT2AATMMAPTTP53 | |
| SCHEMBL333828 | 0.77 | TP53 (0.49) | MEN1KMT2AATMMAPTTP53 | |
| SCHEMBL29059266 | 0.76 | KMT2A (0.75) | MEN1KMT2AMAPTSMN1; SMN2THRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116396205-B | N-aryl indole derivative and preparation method and application thereof | 沈阳药科大学 | 2024-10-01 | — | — | CN | disclosed |
| CN-116396205-A | N-aryl indole derivative and preparation method and application thereof | 沈阳药科大学 | 2023-07-07 | — | — | CN | disclosed |