SCHEMBL29059451

SCHEMBL29059451

O=C(N[C@H](COC1CC1)C(=O)O)OCc1ccccc1

nearest known ligand 0.52

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
HRH1 P35367 1/20 0.52
CTSK P43235 5/20 0.51
IDO1 P14902 1/20 0.51
TDO2 P48775 1/20 0.51
CASP1 P29466 2/20 0.50
PPARA Q07869 2/20 0.50
PPARG P37231 1/20 0.50
CTSL P07711 1/20 0.50
ITGB3 P05106 2/20 0.49
ITGA2B P08514 2/20 0.49
TACR1 P25103 2/20 0.49
ITGAV P06756 1/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL25186346 1.00 HRH1 (0.52) HRH1CTSKIDO1TDO2CASP1
SCHEMBL26125188 0.95 CTSK (0.50) HRH1CTSKIDO1TDO2CASP1
SCHEMBL31456281 0.95 CTSK (0.53) HRH1CTSKIDO1TDO2CASP1
SCHEMBL25178683 0.95 CTSK (0.53) HRH1CTSKIDO1TDO2CASP1
SCHEMBL26128709 0.95 CTSK (0.53) HRH1CTSKIDO1TDO2CASP1
SCHEMBL26125185 0.95 CTSK (0.50) HRH1CTSKIDO1TDO2CASP1
SCHEMBL24324145 0.90 KYNU (0.56) CTSKCTSL
SCHEMBL24324144 0.90 KYNU (0.56) CTSKCTSL
SCHEMBL21314498 0.89 CTSL (0.51) HRH1CTSKIDO1TDO2CASP1
SCHEMBL30588570 0.85 CTSK (0.56) CTSKCTSL

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-116601158-A Modulators of cystic fibrosis transmembrane conductance regulator 弗特克斯药品有限公司 2023-08-15 CN disclosed