Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALK | Q9UM73 | 16/20 | 0.60 |
| ▸ | EGFR | P00533 | 3/20 | 0.60 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.56 |
| ▸ | INSR | P06213 | 1/20 | 0.55 |
| ▸ | IGF1R | P08069 | 1/20 | 0.55 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.55 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.55 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.55 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.55 |
| ▸ | MET | P08581 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21432257 | 0.91 | ALK (0.70) | ALKEGFRMAP3K7INSRIGF1R | |
| SCHEMBL29059677 | 0.87 | ALK (0.61) | ALKEGFRMAP3K7INSRIGF1R | |
| SCHEMBL29059767 | 0.86 | ALK (0.61) | ALKEGFRMAP3K7INSRIGF1R | |
| SCHEMBL29059678 | 0.85 | ALK (0.74) | ALKEGFRINSRIGF1RMAPK3 | |
| SCHEMBL29059672 | 0.83 | ALK (0.58) | ALKEGFRMAP3K7INSRIGF1R | |
| SCHEMBL29059834 | 0.82 | ALK (0.66) | ALKEGFRINSRIGF1RMET | |
| SCHEMBL25872145 | 0.82 | ALK (0.66) | ALKEGFR | |
| SCHEMBL25872232 | 0.82 | ALK (0.59) | ALKEGFRMAP3K7INSRIGF1R | |
| SCHEMBL29059680 | 0.81 | ALK (0.56) | ALKEGFRMAP3K7INSRIGF1R | |
| SCHEMBL29059689 | 0.81 | EGFR (0.75) | ALKEGFRMAP3K7INSRIGF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116490184-A | Compounds for inhibiting EGFR mutant cancers and pharmaceutical uses thereof | J2H生物科技有限公司 | 2023-07-25 | — | — | CN | disclosed |