Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | LOXL2 | Q9Y4K0 | 2/20 | 0.34 |
| ▸ | RAD51 | Q06609 | 1/20 | 0.34 |
| ▸ | SMARCA2 | P51531 | 1/20 | 0.33 |
| ▸ | SMARCA4 | P51532 | 1/20 | 0.33 |
| ▸ | LOX | P28300 | 1/20 | 0.33 |
| ▸ | SYK | P43405 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.32 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.32 |
| ▸ | NT5E | P21589 | 1/20 | 0.31 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.31 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28400269 | 0.81 | HSD11B1 (0.40) | SMN1; SMN2KDM4EALDH1A1LOXL2RAD51 | |
| SCHEMBL484767 | 0.79 | LOXL2 (0.52) | SMN1; SMN2KDM4EALDH1A1LOXL2RAD51 | |
| SCHEMBL29581126 | 0.79 | LOXL2 (0.52) | SMN1; SMN2KDM4EALDH1A1LOXL2RAD51 | |
| SCHEMBL28406030 | 0.78 | SMN1; SMN2 (0.38) | SMN1; SMN2KDM4EALDH1A1LOXL2RAD51 | |
| SCHEMBL29620499 | 0.78 | KDM4E (0.39) | SMN1; SMN2KDM4EALDH1A1LOXL2RAD51 | |
| SCHEMBL20875536 | 0.78 | KDM4E (0.39) | SMN1; SMN2KDM4EALDH1A1LOXL2RAD51 | |
| Bromide SCHEMBL15720464 | 0.78 | LOXL2 (0.50) | SMN1; SMN2KDM4EALDH1A1LOXL2RAD51 | |
| Ammonia Solution, Strong SCHEMBL27910510 | 0.78 | LOXL2 (0.50) | SMN1; SMN2KDM4EALDH1A1LOXL2RAD51 | |
| SCHEMBL15801545 | 0.77 | KDM4E (0.36) | SMN1; SMN2KDM4EALDH1A1LOXL2RAD51 | |
| SCHEMBL3322613 | 0.76 | SMN1; SMN2 (0.42) | SMN1; SMN2KDM4EALDH1A1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116670140-A | Macrocyclic compounds containing 1,3, 4-oxadiazole rings as modulators of cystic fibrosis transmembrane conductance regulator | 弗特克斯药品有限公司 | 2023-08-29 | — | — | CN | disclosed |