Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 1/20 | 0.44 |
| ▸ | JAK1 | P23458 | 1/20 | 0.44 |
| ▸ | TYK2 | P29597 | 1/20 | 0.44 |
| ▸ | JAK3 | P52333 | 1/20 | 0.44 |
| ▸ | DRD2 | P14416 | 5/20 | 0.43 |
| ▸ | MAOB | P27338 | 2/20 | 0.43 |
| ▸ | KDM1A | O60341 | 1/20 | 0.43 |
| ▸ | CA1 | P00915 | 2/20 | 0.41 |
| ▸ | CA2 | P00918 | 2/20 | 0.41 |
| ▸ | CA12 | O43570 | 1/20 | 0.41 |
| ▸ | CA7 | P43166 | 1/20 | 0.41 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.41 |
| ▸ | BTK | Q06187 | 2/20 | 0.39 |
| ▸ | CCR5 | P51681 | 1/20 | 0.39 |
| ▸ | ACACB | O00763 | 1/20 | 0.39 |
| ▸ | KCNA3 | P22001 | 1/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.38 |
| ▸ | DRD3 | P35462 | 1/20 | 0.38 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.38 |
| ▸ | NAMPT | P43490 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6942857 | 0.81 | JAK2 (0.44) | JAK2JAK1TYK2JAK3DRD2 | |
| SCHEMBL29062245 | 0.81 | JAK2 (0.44) | JAK2JAK1TYK2JAK3DRD2 | |
| SCHEMBL28851424 | 0.81 | JAK2 (0.44) | JAK2JAK1TYK2JAK3DRD2 | |
| SCHEMBL29104732 | 0.81 | CA1 (0.41) | DRD2CA1CA2CA12CA7 | |
| SCHEMBL9099580 | 0.77 | ALDH1A1 (0.38) | DRD2CA1CA2CA12CA7 | |
| SCHEMBL29077706 | 0.76 | MAOB (0.42) | JAK2JAK1TYK2JAK3DRD2 | |
| SCHEMBL30421230 | 0.75 | JAK2 (0.43) | JAK2JAK1TYK2JAK3DRD2 | |
| SCHEMBL28570368 | 0.75 | JAK2 (0.43) | JAK2JAK1TYK2JAK3DRD2 | |
| SCHEMBL28414964 | 0.75 | OPRL1 (0.46) | JAK2JAK1TYK2JAK3DRD2 | |
| SCHEMBL30209415 | 0.75 | OPRL1 (0.46) | JAK2JAK1TYK2JAK3DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6753445-B2 | 14-O-((CYCLOALKYL-SULFANYL)ACETYL)-, 14-O-((CYCLOALKYL-ALKYL-SULFANYL)ACETYL)-, 14-O-((CYCLOALKOXY)ACETYL)- AND 14-O-((CYCLOALKYL-ALKOXY) ACETYL) MUTILINS; MICROBIOCIDES | BIOCHEMIE GESELLSCHAFT M.B.H. (AT) | 2004-06-22 | — | — | US | disclosed |
| US-20030162831-A1 | Pleuromutilin derivatives having antibacterial activity | Nabriva Therapeutics GmbH (AT) | 2003-08-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030162831-A1 | Pleuromutilin derivatives having antibacterial activity | MLN, PLEC, ST14 | JAK2 3284/4885JAK1 4579/4885TYK2 4010/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.