SCHEMBL29064876

SCHEMBL29064876

C=CC(=O)Oc1cc(C(F)(F)F)cc(C(F)(F)F)c1

nearest known ligand 0.45

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
CES2 O00748 1/20 0.45
TGM2 P21980 1/20 0.40
THRB P10828 2/20 0.39
RXRA P19793 3/20 0.37
RXRB P28702 3/20 0.37
RXRG P48443 3/20 0.37
MAPT P10636 1/20 0.37
KIF11 P52732 1/20 0.36
RPS6KA3 P51812 1/20 0.36
JAK3 P52333 1/20 0.36
SOD1 P00441 1/20 0.36
TEAD1 P28347 1/20 0.35
TLR8 Q9NR97 1/20 0.35
GPR35 Q9HC97 1/20 0.34
LMNA P02545 1/20 0.34
P2RX1 P51575 1/20 0.34
NOTUM Q6P988 1/20 0.34
GAA P10253 1/20 0.34
SCN9A Q15858 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12592957 0.84 NR1H2 (0.37) TGM2THRBLMNA
SCHEMBL12085342 0.81 KIF11 (0.56) CES2TGM2THRBKIF11TEAD1
SCHEMBL15453565 0.80 CES2 (0.41) CES2TGM2RXRARXRBRXRG
SCHEMBL15453834 0.79 CES2 (0.52) CES2RXRARXRBRXRGMAPT
Hydrochloric Acid SCHEMBL27901791 0.79 KIF11 (0.54) CES2TGM2THRBKIF11TEAD1
SCHEMBL11850804 0.79 THRB (0.48) TGM2THRBMAPTLMNA
SCHEMBL20280800 0.79 NR1H2 (0.33) THRB
SCHEMBL18844152 0.79 THRB (0.36) THRB
SCHEMBL7647561 0.78 CES2 (0.50) CES2RXRARXRBRXRGMAPT
SCHEMBL21162451 0.77 THRB (0.36) TGM2THRB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-116789517-A Aryl or heteroaryl derivative and organic electroluminescent element comprising same 株式会社乐普拓 2023-09-22 CN disclosed
CN-116710432-A Organic compound and organic electroluminescent device comprising the same 株式会社乐普拓 2023-09-05 CN disclosed