Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 19/20 | 0.39 |
| ▸ | THRA | P10827 | 17/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.37 |
| ▸ | UGT1A1 | P22309 | 1/20 | 0.37 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.37 |
| ▸ | SLCO1B1 | Q9Y6L6 | 1/20 | 0.37 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24407939 | 0.85 | THRB (0.48) | THRBTHRACYP2C9UGT1A1ABCG2 | |
| SCHEMBL29066234 | 0.83 | THRA (0.49) | THRBTHRACYP2C9UGT1A1ABCG2 | |
| SCHEMBL29066211 | 0.83 | THRB (0.48) | THRBTHRACYP2C9UGT1A1ABCG2 | |
| SCHEMBL29527864 | 0.78 | THRB (0.56) | THRBTHRACYP2C9UGT1A1ABCG2 | |
| SCHEMBL24408118 | 0.78 | THRB (0.54) | THRBTHRACYP2C9UGT1A1ABCG2 | |
| SCHEMBL29527275 | 0.76 | THRB (0.41) | THRBTHRACYP2C9UGT1A1ABCG2 | |
| SCHEMBL29066198 | 0.76 | THRB (0.54) | THRBTHRACYP2C9UGT1A1ABCG2 | |
| SCHEMBL29527059 | 0.71 | THRB (0.37) | THRBTHRA | |
| SCHEMBL29066207 | 0.70 | THRB (0.47) | THRBTHRACYP2C9UGT1A1ABCG2 | |
| SCHEMBL24450095 | 0.69 | THRA (0.70) | THRBTHRACYP2C9UGT1A1ABCG2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116710443-A | 2-pyridones as thyroid hormone receptor modulators | 阿利戈斯治疗公司 | 2023-09-05 | — | — | CN | disclosed |