Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.37 |
| ▸ | SHMT2 | P34897 | 1/20 | 0.36 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.35 |
| ▸ | MTOR | P42345 | 1/20 | 0.35 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.34 |
| ▸ | NNMT | P40261 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.33 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.33 |
| ▸ | SIK1 | P57059 | 1/20 | 0.33 |
| ▸ | SIK2 | Q9H0K1 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29066233 | 0.82 | DYRK1A (0.36) | MAPTSIRT6DYRK1ANNMTALDH1A1 | |
| SCHEMBL16554531 | 0.82 | SQOR (0.38) | SIRT6PIK3CADYRK1ANNMTPOLB | |
| SCHEMBL16936117 | 0.81 | DYRK1A (0.35) | MAPTSIRT6DYRK1ANNMTALDH1A1 | |
| SCHEMBL8916 | 0.79 | PIK3CA (0.49) | MAPTSHMT2PIK3CAMTORHTT | |
| SCHEMBL29611762 | 0.79 | PIK3CA (0.49) | MAPTSHMT2PIK3CAMTORHTT | |
| SCHEMBL28702184 | 0.78 | AAK1 (0.32) | MAPTHTTAAK1KMT2A | |
| SCHEMBL28527777 | 0.78 | KMT2A (0.47) | MAPTSHMT2DYRK1AHTTPOLB | |
| SCHEMBL28705730 | 0.77 | SMN1; SMN2 (0.44) | MAPTALDH1A1KMT2A | |
| SCHEMBL8125788 | 0.77 | NNMT (0.46) | MAPTSIRT6NNMTALDH1A1POLB | |
| SCHEMBL20639934 | 0.77 | DGAT1 (0.40) | MAPTHTTALDH1A1POLBMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116710443-A | 2-pyridones as thyroid hormone receptor modulators | 阿利戈斯治疗公司 | 2023-09-05 | — | — | CN | disclosed |