Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN11 | Q06124 | 6/20 | 0.41 |
| ▸ | EGFR | P00533 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | CNR2 | P34972 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28710336 | 0.82 | PTPN11 (0.38) | PTPN11EGFRKCNH2 | |
| SCHEMBL21115199 | 0.80 | PTPN11 (0.39) | PTPN11EGFRKCNH2 | |
| SCHEMBL23070920 | 0.78 | PTPN11 (0.42) | PTPN11EGFRKCNH2 | |
| SCHEMBL28906903 | 0.77 | PTPN11 (0.41) | PTPN11EGFRKCNH2 | |
| SCHEMBL30538222 | 0.76 | RET (0.36) | PTPN11CNR2 | |
| SCHEMBL23083510 | 0.75 | PTPN11 (0.33) | PTPN11 | |
| SCHEMBL29041452 | 0.75 | CNR1 (0.36) | PTPN11 | |
| SCHEMBL28945530 | 0.74 | PTPN11 (0.32) | PTPN11CNR2 | |
| SCHEMBL21115087 | 0.73 | PTPN11 (0.35) | PTPN11EGFRKCNH2 | |
| SCHEMBL21115294 | 0.73 | PTPN11 (0.35) | PTPN11EGFRKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116478131-A | 2, 5-disubstituted and 2,5, 6-trisubstituted 3-methylpyrazines as allosteric SHP2 inhibitors | 锐新医药公司 | 2023-07-25 | — | — | CN | disclosed |
| CN-109983001-B | 2, 5-disubstituted 3-methylpyrazines and 2,5, 6-trisubstituted 3-methylpyrazines as allosteric SHP2 inhibitors | 锐新医药公司 | 2023-04-04 | — | — | CN | disclosed |