Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN11 | Q06124 | 18/20 | 0.41 |
| ▸ | EGFR | P00533 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.32 |
| ▸ | MTOR | P42345 | 1/20 | 0.32 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28520538 | 0.84 | PTPN11 (0.32) | PTPN11 | |
| SCHEMBL28945530 | 0.79 | PTPN11 (0.32) | PTPN11PIK3CAMTORSCN10A | |
| SCHEMBL23063935 | 0.78 | PTPN11 (0.38) | PTPN11SCN10A | |
| SCHEMBL29070211 | 0.77 | PTPN11 (0.41) | PTPN11EGFRKCNH2 | |
| SCHEMBL28793472 | 0.77 | PTPN11 (0.36) | PTPN11PIK3CAMTOR | |
| SCHEMBL29097721 | 0.76 | HCRTR2 (0.38) | PTPN11 | |
| SCHEMBL23126464 | 0.76 | RET (0.41) | PTPN11 | |
| SCHEMBL28679105 | 0.76 | PANK3 (0.42) | PTPN11 | |
| SCHEMBL23500914 | 0.71 | P2RX7 (0.42) | PTPN11 | |
| SCHEMBL28793429 | 0.69 | KDM4E (0.36) | PTPN11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112351780-B | Substituted heterocyclic inhibitors of PTPN11 | 纳维尔制药有限公司 | 2023-12-01 | — | — | CN | disclosed |
| CN-112351780-A | Substituted heterocyclic inhibitors of PTPN11 | 纳维尔制药有限公司 | 2021-02-09 | — | — | CN | disclosed |