Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TBK1 | Q9UHD2 | 19/20 | 0.56 |
| ▸ | IKBKE | Q14164 | 10/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.56 |
| ▸ | NPC1 | O15118 | 1/20 | 0.56 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.56 |
| ▸ | TTR | P02766 | 1/20 | 0.56 |
| ▸ | GAA | P10253 | 1/20 | 0.56 |
| ▸ | PKM | P14618 | 1/20 | 0.56 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.56 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.56 |
| ▸ | RAB9A | P51151 | 1/20 | 0.56 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.56 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.56 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10347100 | 0.86 | TBK1 (0.72) | TBK1IKBKEKDM4ENPC1ABCC4 | |
| SCHEMBL11100703 | 0.85 | TBK1 (0.47) | TBK1IKBKEKDM4ENPC1ABCC4 | |
| SCHEMBL11102394 | 0.83 | TBK1 (0.48) | TBK1IKBKEKDM4ENPC1ABCC4 | |
| SCHEMBL2901850 | 0.83 | TBK1 (0.72) | TBK1IKBKEKDM4ENPC1ABCC4 | |
| SCHEMBL2908311 | 0.82 | TBK1 (0.71) | TBK1IKBKEKDM4ENPC1ABCC4 | |
| SCHEMBL2908309 | 0.82 | TBK1 (0.71) | TBK1IKBKEKDM4ENPC1ABCC4 | |
| SCHEMBL2908306 | 0.79 | TBK1 (0.57) | TBK1IKBKEKDM4ENPC1ABCC4 | |
| SCHEMBL11107442 | 0.79 | TBK1 (0.51) | TBK1IKBKEKDM4ENPC1ABCC4 | |
| SCHEMBL11358113 | 0.78 | TBK1 (0.53) | TBK1IKBKEKDM4ENPC1ABCC4 | |
| SCHEMBL10514251 | 0.76 | TBK1 (0.59) | TBK1IKBKEKDM4ENPC1ABCC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1758857-B1 | INDOLE DERIVATIVES AS ANTIVIRAL AGENTS | ANGELETTI P IST RICHERCHE BIO (IT) | 2010-08-18 | — | — | EP | disclosed |