Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 4/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.55 |
| ▸ | MAPT | P10636 | 6/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.40 |
| ▸ | GSR | P00390 | 1/20 | 0.39 |
| ▸ | TXNRD1 | Q16881 | 1/20 | 0.39 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | MERTK | Q12866 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22120606 | 0.87 | POLB (0.56) | POLBTDP1L3MBTL1MAPTALDH1A1 | |
| SCHEMBL29074137 | 0.86 | MAPT (0.50) | POLBTDP1L3MBTL1MAPTALDH1A1 | |
| SCHEMBL101570 | 0.84 | ALDH1A1 (0.69) | POLBTDP1L3MBTL1MAPTALDH1A1 | |
| SCHEMBL30434695 | 0.80 | POLB (0.58) | POLBTDP1L3MBTL1MAPTALDH1A1 | |
| SCHEMBL9564464 | 0.80 | POLB (0.58) | POLBTDP1L3MBTL1MAPTALDH1A1 | |
| SCHEMBL952111 | 0.80 | POLB (0.58) | POLBTDP1L3MBTL1MAPTALDH1A1 | |
| SCHEMBL3239219 | 0.80 | CYP1A2 (0.59) | POLBTDP1L3MBTL1MAPTALDH1A1 | |
| SCHEMBL23536074 | 0.79 | POLB (0.48) | POLBTDP1L3MBTL1MAPTALDH1A1 | |
| SCHEMBL3538908 | 0.78 | TDP1 (0.59) | POLBTDP1L3MBTL1MAPTALDH1A1 | |
| SCHEMBL9437331 | 0.77 | L3MBTL1 (0.64) | POLBTDP1L3MBTL1MAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116554151-B | Kinesin KIF18A inhibitor and application thereof | 上海湃隆生物科技有限公司 | 2024-09-20 | — | — | CN | disclosed |
| CN-116554151-A | Kinesin KIF18A inhibitor and application thereof | 上海湃隆生物科技有限公司 | 2023-08-08 | — | — | CN | disclosed |