Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.69 |
| ▸ | MAPK1 | P28482 | 5/20 | 0.69 |
| ▸ | POLB | P06746 | 5/20 | 0.69 |
| ▸ | MAPT | P10636 | 4/20 | 0.69 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.69 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.62 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.56 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.56 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.56 |
| ▸ | LMNA | P02545 | 3/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | USP2 | O75604 | 1/20 | 0.48 |
| ▸ | TNNI3 | P19429 | 1/20 | 0.48 |
| ▸ | TNNT2 | P45379 | 1/20 | 0.48 |
| ▸ | TNNC1 | P63316 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | GSR | P00390 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL952111 | 0.86 | POLB (0.58) | ALDH1A1MAPK1POLBMAPTTDP1 | |
| SCHEMBL3239219 | 0.86 | CYP1A2 (0.59) | ALDH1A1MAPK1POLBMAPTTDP1 | |
| SCHEMBL30434695 | 0.86 | POLB (0.58) | ALDH1A1MAPK1POLBMAPTTDP1 | |
| SCHEMBL9564464 | 0.86 | POLB (0.58) | ALDH1A1MAPK1POLBMAPTTDP1 | |
| SCHEMBL22120606 | 0.85 | POLB (0.56) | ALDH1A1MAPK1POLBMAPTTDP1 | |
| SCHEMBL11654178 | 0.84 | ALDH1A1 (0.69) | ALDH1A1MAPK1POLBMAPTTDP1 | |
| SCHEMBL3538908 | 0.84 | TDP1 (0.59) | ALDH1A1MAPK1POLBMAPTTDP1 | |
| SCHEMBL29074136 | 0.84 | POLB (0.55) | ALDH1A1MAPK1POLBMAPTTDP1 | |
| SCHEMBL9437331 | 0.83 | L3MBTL1 (0.64) | ALDH1A1MAPK1POLBMAPTTDP1 | |
| SCHEMBL2416386 | 0.82 | ALDH1A1 (1.00) | ALDH1A1MAPK1POLBMAPTTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120059037-A1 | SUBSTITUTED PYRIDINE DERIVATIVES AND THEIR MEDICAL USE | NEUROSEARCH A/S (DK) | 2012-03-08 | — | — | US | disclosed |
| US-20120059037-A1 | SUBSTITUTED PYRIDINE DERIVATIVES AND THEIR MEDICAL USE | NEUROSEARCH A/S (DK) | 2012-03-08 | — | — | US | disclosed |
| US-20120059037-A1 | SUBSTITUTED PYRIDINE DERIVATIVES AND THEIR MEDICAL USE | NEUROSEARCH A/S (DK) | 2012-03-08 | — | — | US | disclosed |
| EP-2408747-A1 | SUBSTITUTED PYRIDINE DERIVATIVES AND THEIR MEDICAL USE | NeuroSearch A/S (DK) | 2012-01-25 | — | — | EP | disclosed |
| US-20110039896-A1 | NOVEL 2-PYRROLIDINYL-3-AMIDO-6-AMINO-PYRIDINE DERIVATIVES USEFUL AS POTASSIUM CHANNEL ACTIVATORS | NEUROSEARCH A/S (DK) | 2011-02-17 | — | — | US | disclosed |
| US-20110039896-A1 | NOVEL 2-PYRROLIDINYL-3-AMIDO-6-AMINO-PYRIDINE DERIVATIVES USEFUL AS POTASSIUM CHANNEL ACTIVATORS | NEUROSEARCH A/S (DK) | 2011-02-17 | — | — | US | disclosed |
| US-20110039896-A1 | NOVEL 2-PYRROLIDINYL-3-AMIDO-6-AMINO-PYRIDINE DERIVATIVES USEFUL AS POTASSIUM CHANNEL ACTIVATORS | NEUROSEARCH A/S (DK) | 2011-02-17 | — | — | US | disclosed |
| EP-2231611-A1 | NOVEL 2-PYRROLIDINYL-3-AMIDO-6-AMINO-PYRIDINE DERIVATIVES USEFUL AS POTASSIUM CHANNEL ACTIVATORS | NeuroSearch A/S (DK) | 2010-09-29 | — | — | EP | disclosed |
| WO-2010105960-A1 | SUBSTITUTED PYRIDINE DERIVATIVES AND THEIR MEDICAL USE | NEUROSEARCH A/S (DK) | 2010-09-23 | — | — | WO | disclosed |
| WO-2010105960-A1 | SUBSTITUTED PYRIDINE DERIVATIVES AND THEIR MEDICAL USE | NEUROSEARCH A/S (DK) | 2010-09-23 | — | — | WO | disclosed |
| WO-2010026104-A1 | 4-TETRAHYDROPYRAN-AMINOPYRIDINE DERIVATIVES AND THEIR MEDICAL USE | NEUROSEARCH A/S (DK) | 2010-03-11 | — | — | WO | disclosed |
| WO-2010026104-A1 | 4-TETRAHYDROPYRAN-AMINOPYRIDINE DERIVATIVES AND THEIR MEDICAL USE | NEUROSEARCH A/S (DK) | 2010-03-11 | — | — | WO | disclosed |
| WO-2009074593-A1 | NOVEL 2-PYRROLIDINYL-3-AMIDO-6-AMINO-PYRIDINE DERIVATIVES USEFUL AS POTASSIUM CHANNEL ACTIVATORS | NEUROSEARCH A/S (DK) | 2009-06-18 | — | — | WO | disclosed |
| WO-2009074593-A1 | NOVEL 2-PYRROLIDINYL-3-AMIDO-6-AMINO-PYRIDINE DERIVATIVES USEFUL AS POTASSIUM CHANNEL ACTIVATORS | NEUROSEARCH A/S (DK) | 2009-06-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110039896-A1 | NOVEL 2-PYRROLIDINYL-3-AMIDO-6-AMINO-PYRIDINE DERIVATIVES USEFUL AS POTASSIUM CHANNEL ACTIVATORS | KCNA7, KCNJ2, KCNN3 | ALDH1A1 3708/4885MAPK1 1976/4885POLB 4555/4885 |
| US-20120059037-A1 | SUBSTITUTED PYRIDINE DERIVATIVES AND THEIR MEDICAL USE | KCNA7, KCNQ1, KCNQ2 | ALDH1A1 3417/4885MAPK1 2065/4885POLB 3756/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.