SCHEMBL29074232

SCHEMBL29074232

c1ccc(-c2cccc(Nc3nccs3)n2)nc1

nearest known ligand 0.56

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KCNN1 Q92952 2/20 0.56
KCNN2 Q9H2S1 2/20 0.56
KCNN3 Q9UGI6 2/20 0.56
MBD2 Q9UBB5 2/20 0.56
MECP2 P51608 1/20 0.56
SMN1; SMN2 Q16637 6/20 0.56
MEN1 O00255 5/20 0.56
KMT2A Q03164 5/20 0.56
NPC1 O15118 5/20 0.56
RAB9A P51151 5/20 0.56
TP53 P04637 4/20 0.56
MAPT P10636 4/20 0.56
NFKB1 P19838 4/20 0.56
NFKB2 Q00653 4/20 0.56
RELA Q04206 4/20 0.56
TDP1 Q9NUW8 3/20 0.56
POLB P06746 3/20 0.56
ALPL P05186 2/20 0.56
PPP1CA P62136 2/20 0.56
ALDH1A1 P00352 2/20 0.56

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3139644 0.84 KCNN1 (0.49) KCNN1KCNN2KCNN3MBD2MECP2
SCHEMBL2066398 0.82 MECP2 (0.54) KCNN1KCNN2KCNN3MBD2MECP2
SCHEMBL29933008 0.82 MECP2 (0.54) KCNN1KCNN2KCNN3MBD2MECP2
SCHEMBL20919383 0.82 KDM4E (0.68) KCNN1KCNN2KCNN3MBD2MECP2
Bromide SCHEMBL7508960 0.80 MECP2 (0.53) KCNN1KCNN2KCNN3MBD2MECP2
SCHEMBL29074227 0.79 KCNN1 (0.54) KCNN1KCNN2KCNN3MBD2MECP2
SCHEMBL6368488 0.79 MAPT (0.68) KCNN1KCNN2KCNN3MBD2MECP2
SCHEMBL29074215 0.77 KARS1 (0.56) SMN1; SMN2MEN1KMT2ANPC1RAB9A
SCHEMBL30608758 0.77 KARS1 (0.56) SMN1; SMN2MEN1KMT2ANPC1RAB9A
SCHEMBL19782866 0.77 KDM4E (0.61) KCNN1KCNN2KCNN3MBD2MECP2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-116751195-B Bipyridine compound, pharmaceutically acceptable salt thereof, preparation method and application 杭州科兴生物化工有限公司 2025-03-07 CN disclosed
CN-116751195-A Bipyridine compound, pharmaceutically acceptable salt thereof, preparation method and application 杭州科兴生物化工有限公司 2023-09-15 CN disclosed