Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.68 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.68 |
| ▸ | NFKB1 | P19838 | 3/20 | 0.68 |
| ▸ | NFKB2 | Q00653 | 3/20 | 0.68 |
| ▸ | RELA | Q04206 | 3/20 | 0.68 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.68 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.68 |
| ▸ | MEN1 | O00255 | 3/20 | 0.68 |
| ▸ | PPP1CA | P62136 | 2/20 | 0.68 |
| ▸ | KCNN1 | Q92952 | 2/20 | 0.68 |
| ▸ | KCNN2 | Q9H2S1 | 2/20 | 0.68 |
| ▸ | MBD2 | Q9UBB5 | 2/20 | 0.68 |
| ▸ | KCNN3 | Q9UGI6 | 2/20 | 0.68 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.68 |
| ▸ | MECP2 | P51608 | 1/20 | 0.68 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.62 |
| ▸ | VCP | P55072 | 1/20 | 0.62 |
| ▸ | SLC2A1 | P11166 | 5/20 | 0.60 |
| ▸ | NPC1 | O15118 | 3/20 | 0.60 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7678939 | 0.91 | MAPT (0.81) | MAPTKMT2ANFKB1NFKB2RELA | |
| Bromide SCHEMBL7673197 | 0.89 | MAPT (0.79) | MAPTKMT2ANFKB1NFKB2RELA | |
| SCHEMBL1821615 | 0.83 | MEN1 (0.68) | MAPTKMT2ANFKB1NFKB2RELA | |
| SCHEMBL6368825 | 0.83 | MAPT (0.74) | MAPTKMT2ANFKB1NFKB2RELA | |
| SCHEMBL29602125 | 0.83 | MAPT (0.74) | MAPTKMT2ANFKB1NFKB2RELA | |
| SCHEMBL12639826 | 0.81 | SMN1; SMN2 (1.00) | MAPTKMT2ANFKB1NFKB2RELA | |
| SCHEMBL5155715 | 0.81 | KCNN1 (1.00) | MAPTKMT2ANFKB1NFKB2RELA | |
| SCHEMBL30745771 | 0.81 | KCNN1 (1.00) | MAPTKMT2ANFKB1NFKB2RELA | |
| SCHEMBL29074232 | 0.79 | KCNN1 (0.56) | MAPTKMT2ANFKB1NFKB2RELA | |
| SCHEMBL1887374 | 0.77 | VCP (1.00) | MAPTKMT2ANFKB1NFKB2RELA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050227989-A1 | Polycyclic thiazoles as potassium ion channel modulators | ICAGEN, INC. (US) | 2005-10-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050227989-A1 | Polycyclic thiazoles as potassium ion channel modulators | KCNJ2, KCNA3, KCNN3 | MAPT 2993/4885KMT2A 809/4885NFKB1 2573/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.