Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.44 |
| ▸ | ESR1 | P03372 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | TTR | P02766 | 2/20 | 0.41 |
| ▸ | IDH1 | O75874 | 1/20 | 0.40 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.40 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.39 |
| ▸ | TACR1 | P25103 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.36 |
| ▸ | MET | P08581 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14483814 | 0.82 | ESR1 (0.40) | ALDH1A1CYP3A4ESR1MAPK1MEN1 | |
| SCHEMBL5666942 | 0.81 | ALDH1A1 (0.64) | ALDH1A1CYP3A4SMN1; SMN2IDH1HSD17B10 | |
| SCHEMBL3333980 | 0.80 | CA2 (0.54) | ALDH1A1CYP3A4MAPK1MEN1KMT2A | |
| SCHEMBL19189859 | 0.80 | ESR1 (0.41) | ALDH1A1ESR1MAPK1MEN1KMT2A | |
| SCHEMBL18735629 | 0.80 | ALDH1A1 (0.53) | ALDH1A1CYP3A4ESR1IDH1CA2 | |
| SCHEMBL13034131 | 0.80 | ALDH1A1 (0.53) | ALDH1A1CYP3A4MAPK1MEN1KMT2A | |
| SCHEMBL12160553 | 0.79 | ALDH1A1 (0.57) | ALDH1A1CYP3A4MEN1KMT2AIDH1 | |
| SCHEMBL13034149 | 0.79 | MEN1 (0.58) | ALDH1A1CYP3A4MAPK1MEN1KMT2A | |
| SCHEMBL760923 | 0.79 | ALDH1A1 (0.48) | ALDH1A1CYP3A4MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL7566203 | 0.78 | ALDH1A1 (0.52) | ALDH1A1CYP3A4IDH1S1PR4HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116761795-A | Inhibitors of Transcription Enhancement Associated Domain (TEAD) and uses thereof | 达纳-法伯癌症研究所股份有限公司 | 2023-09-15 | — | — | CN | disclosed |