Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 4/20 | 0.53 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.40 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | ACHE | P22303 | 2/20 | 0.38 |
| ▸ | BCHE | P06276 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | BRD4 | O60885 | 1/20 | 0.37 |
| ▸ | EHMT2 | Q96KQ7 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1189916 | 1.00 | P2RX7 (0.53) | P2RX7HCRTR1HCRTR2MEN1KMT2A | |
| SCHEMBL10215490 | 0.85 | P2RX7 (0.56) | P2RX7HCRTR1HCRTR2MEN1KMT2A | |
| SCHEMBL1190522 | 0.85 | P2RX7 (0.58) | P2RX7HCRTR1HCRTR2MEN1KMT2A | |
| SCHEMBL1005866 | 0.85 | P2RX7 (0.58) | P2RX7HCRTR1HCRTR2MEN1KMT2A | |
| SCHEMBL311394 | 0.85 | P2RX7 (0.58) | P2RX7HCRTR1HCRTR2MEN1KMT2A | |
| SCHEMBL6179978 | 0.84 | P2RX7 (0.57) | P2RX7HCRTR1HCRTR2MEN1KMT2A | |
| SCHEMBL6179972 | 0.84 | P2RX7 (0.57) | P2RX7HCRTR1HCRTR2MEN1KMT2A | |
| SCHEMBL10270030 | 0.83 | P2RX7 (0.57) | P2RX7HCRTR1HCRTR2MEN1KMT2A | |
| SCHEMBL3337871 | 0.83 | P2RX7 (0.57) | P2RX7HCRTR1HCRTR2MEN1KMT2A | |
| SCHEMBL3333492 | 0.83 | P2RX7 (0.56) | P2RX7HCRTR1HCRTR2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2217226-A1 | PEPTIDE DEFORMYLASE INHIBITORS | GlaxoSmithKline LLC (US) | 2010-08-18 | — | — | EP | disclosed |
| WO-2009061879-A1 | PEPTIDE DEFORMYLASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2009-05-14 | — | — | WO | disclosed |