Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 4/20 | 0.56 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | CAPN1 | P07384 | 3/20 | 0.43 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.42 |
| ▸ | MAOB | P27338 | 1/20 | 0.40 |
| ▸ | SPHK1 | Q9NYA1 | 1/20 | 0.40 |
| ▸ | EHMT2 | Q96KQ7 | 1/20 | 0.40 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.39 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.39 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1005866 | 0.89 | P2RX7 (0.58) | P2RX7CYP2C9CYP2C19CAPN1EHMT2 | |
| SCHEMBL1190522 | 0.89 | P2RX7 (0.58) | P2RX7CYP2C9CYP2C19CAPN1EHMT2 | |
| SCHEMBL311394 | 0.89 | P2RX7 (0.58) | P2RX7CYP2C9CYP2C19CAPN1EHMT2 | |
| SCHEMBL6179978 | 0.87 | P2RX7 (0.57) | P2RX7CYP2C9CYP2C19CAPN1EHMT2 | |
| SCHEMBL6179972 | 0.87 | P2RX7 (0.57) | P2RX7CYP2C9CYP2C19CAPN1EHMT2 | |
| SCHEMBL10215490 | 0.86 | P2RX7 (0.56) | P2RX7EHMT2HCRTR1HCRTR2KMT2A | |
| SCHEMBL3337871 | 0.84 | P2RX7 (0.57) | P2RX7HCRTR1HCRTR2KMT2AMEN1 | |
| SCHEMBL10270030 | 0.84 | P2RX7 (0.57) | P2RX7HCRTR1HCRTR2KMT2AMEN1 | |
| SCHEMBL2907566 | 0.83 | P2RX7 (0.53) | P2RX7CYP2C19EHMT2HCRTR1HCRTR2 | |
| SCHEMBL1189916 | 0.83 | P2RX7 (0.53) | P2RX7CYP2C19EHMT2HCRTR1HCRTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100144727-A1 | Oxazolidine and Morpholine Carboxamide Derivatives as P2X7 Modulators | BESWICK PAUL JOHN | 2010-06-10 | — | — | US | disclosed |
| EP-2139875-A2 | OXAZOLIDINE AND MORPHOLINE CARBOXAMIDE DERIVATIVES AS P2X7 MODULATORS | Glaxo Group Limited (GB) | 2010-01-06 | — | — | EP | disclosed |
| WO-2008119685-A2 | OXAZOLIDINE AND MORPHOLINE CARBOXAMIDE DERIVATIVES AS P2X7 MODULATORS | GLAXO GROUP LIMITED (GB) | 2008-10-09 | — | — | WO | disclosed |
| CN-1059339-A | New quinoline carboxylic acid derivative, the antiseptic-germicide that contains them and their method for making | KANEBO LTD (JP) | 1992-03-11 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100144727-A1 | Oxazolidine and Morpholine Carboxamide Derivatives as P2X7 Modulators | P2RX5, P2RX3, P2RX7 | P2RX7 3/4885CYP2C9 598/4885CYP2C19 622/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.