Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 9/20 | 0.66 |
| ▸ | TP53 | P04637 | 3/20 | 0.66 |
| ▸ | AURKB | Q96GD4 | 5/20 | 0.54 |
| ▸ | AURKA | O14965 | 3/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.52 |
| ▸ | GAA | P10253 | 2/20 | 0.52 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.52 |
| ▸ | THRB | P10828 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 3/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | CA2 | P00918 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | CLK1 | P49759 | 1/20 | 0.49 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2913350 | 0.89 | MAPT (0.59) | MAPTTP53AURKBAURKASMN1; SMN2 | |
| SCHEMBL2904906 | 0.89 | MAPT (0.58) | MAPTTP53AURKBAURKASMN1; SMN2 | |
| SCHEMBL2910608 | 0.87 | AURKB (0.61) | MAPTTP53AURKBAURKASMN1; SMN2 | |
| SCHEMBL2912034 | 0.87 | AURKB (0.59) | MAPTTP53AURKBAURKASMN1; SMN2 | |
| SCHEMBL2908274 | 0.86 | CA2 (0.61) | MAPTTP53AURKBAURKASMN1; SMN2 | |
| SCHEMBL2912397 | 0.86 | CA2 (0.61) | MAPTTP53SMN1; SMN2GAATHRB | |
| SCHEMBL2913228 | 0.86 | MAPT (0.61) | MAPTTP53AURKBAURKASMN1; SMN2 | |
| SCHEMBL2904271 | 0.84 | MAPT (0.58) | MAPTTP53AURKBGAATHRB | |
| SCHEMBL2912044 | 0.83 | CSF1R (0.59) | MAPTTP53AURKBAURKAGAA | |
| SCHEMBL4081004 | 0.82 | MAPT (0.58) | MAPTTP53AURKBSMN1; SMN2GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2010496-B1 | 4-ANILINOQUINOLINE-3-CARBOXAMIDES AS CSF-1R KINASE INHIBITORS | ASTRAZENECA AB (SE) | 2010-08-25 | — | — | EP | disclosed |