Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKB | Q96GD4 | 6/20 | 0.61 |
| ▸ | AURKA | O14965 | 4/20 | 0.60 |
| ▸ | CSF1R | P07333 | 1/20 | 0.58 |
| ▸ | TP53 | P04637 | 4/20 | 0.57 |
| ▸ | MAPT | P10636 | 4/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.55 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.55 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.55 |
| ▸ | CA2 | P00918 | 1/20 | 0.55 |
| ▸ | PKM | P14618 | 1/20 | 0.54 |
| ▸ | STK4 | Q13043 | 1/20 | 0.54 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | EGFR | P00533 | 1/20 | 0.51 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2912034 | 0.91 | AURKB (0.59) | AURKBAURKATP53MAPTKDM4E | |
| SCHEMBL2913228 | 0.91 | MAPT (0.61) | AURKBAURKACSF1RTP53MAPT | |
| SCHEMBL2907589 | 0.87 | MAPT (0.66) | AURKBAURKATP53MAPTKDM4E | |
| SCHEMBL2913350 | 0.86 | MAPT (0.59) | AURKBAURKATP53MAPTALDH1A1 | |
| SCHEMBL2904906 | 0.86 | MAPT (0.58) | AURKBAURKACSF1RTP53MAPT | |
| SCHEMBL23575246 | 0.84 | MAPT (0.61) | AURKBAURKATP53MAPTKDM4E | |
| SCHEMBL2912044 | 0.84 | CSF1R (0.59) | AURKBAURKACSF1RTP53MAPT | |
| SCHEMBL2908274 | 0.83 | CA2 (0.61) | AURKBAURKACSF1RTP53MAPT | |
| SCHEMBL2912397 | 0.83 | CA2 (0.61) | CSF1RTP53MAPTSMN1; SMN2CA2 | |
| SCHEMBL2911359 | 0.83 | CSF1R (0.59) | AURKBAURKACSF1RTP53MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2010496-B1 | 4-ANILINOQUINOLINE-3-CARBOXAMIDES AS CSF-1R KINASE INHIBITORS | ASTRAZENECA AB (SE) | 2010-08-25 | — | — | EP | disclosed |