Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 1/20 | 0.53 |
| ▸ | POLB | P06746 | 2/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 4/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.45 |
| ▸ | ESR1 | P03372 | 1/20 | 0.44 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.44 |
| ▸ | GABBR2 | O75899 | 3/20 | 0.43 |
| ▸ | GABBR1 | Q9UBS5 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.43 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.43 |
| ▸ | DRD3 | P35462 | 1/20 | 0.43 |
| ▸ | BLM | P54132 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13025499 | 0.84 | CYP2C9 (0.46) | BRD4POLBCYP2C9CYP2C19L3MBTL1 | |
| SCHEMBL28233461 | 0.82 | BRD4 (0.55) | BRD4POLBCYP2C9CYP2C19L3MBTL1 | |
| SCHEMBL4444979 | 0.82 | BRD4 (0.55) | BRD4POLBCYP2C9CYP2C19L3MBTL1 | |
| SCHEMBL8217885 | 0.81 | BRD4 (0.53) | BRD4POLBCYP2C9CYP2C19KMT2A | |
| SCHEMBL2915594 | 0.80 | ALDH1A1 (0.46) | POLBCYP2C9CYP2C19L3MBTL1KMT2A | |
| SCHEMBL2915242 | 0.80 | ALDH1A1 (0.46) | POLBCYP2C9CYP2C19L3MBTL1KMT2A | |
| SCHEMBL1977280 | 0.80 | ALDH1A1 (0.46) | POLBCYP2C9CYP2C19L3MBTL1KMT2A | |
| SCHEMBL5321358 | 0.78 | BRD4 (0.50) | BRD4POLBCYP2C9CYP2C19KMT2A | |
| SCHEMBL27573299 | 0.78 | AOC3 (0.50) | BRD4POLBCYP2C9CYP2C19KMT2A | |
| SCHEMBL27573301 | 0.78 | AOC3 (0.50) | BRD4POLBCYP2C9CYP2C19KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8309742-B2 | Use of the PigD protein for catalyzing 1,4-additions of 2-oxoalkanoates to α, β-unsaturated ketones | ALBERT-LUDWIGS-UNIVERSITAT FREIBURG (DE) | 2012-11-13 | — | — | US | disclosed |
| US-8309742-B2 | Use of the PigD protein for catalyzing 1,4-additions of 2-oxoalkanoates to α, β-unsaturated ketones | ALBERT-LUDWIGS-UNIVERSITAT FREIBURG (DE) | 2012-11-13 | — | — | US | disclosed |
| US-20100305337-A1 | Use Of The PIGD Protein For Catalyzing 1,4-Additions Of 2-Oxoalkanoates To Alpha, Beta-Unsaturated Ketones | ALBERT-LUDWIGS-UNIVERSITAT FREIBURG (DE) | 2010-12-02 | — | — | US | disclosed |
| US-20100305337-A1 | Use Of The PIGD Protein For Catalyzing 1,4-Additions Of 2-Oxoalkanoates To Alpha, Beta-Unsaturated Ketones | ALBERT-LUDWIGS-UNIVERSITAT FREIBURG (DE) | 2010-12-02 | — | — | US | disclosed |
| EP-2142657-B1 | USE OF THE PIGD PROTEIN FOR CATALYZING 1,4-ADDITIONS OF 2-OXOALKANOATES TO ALPHA, BETA-UNSATURATED KETONES | UNIV ALBERT LUDWIGS FREIBURG (DE) | 2010-09-01 | — | — | EP | disclosed |
| EP-2142657-B1 | USE OF THE PIGD PROTEIN FOR CATALYZING 1,4-ADDITIONS OF 2-OXOALKANOATES TO ALPHA, BETA-UNSATURATED KETONES | UNIV ALBERT LUDWIGS FREIBURG (DE) | 2010-09-01 | — | — | EP | disclosed |
| EP-2142657-A1 | USE OF THE PIGD PROTEIN FOR CATALYZING 1,4-ADDITIONS OF 2-OXOALKANOATES TO ALPHA, BETA-UNSATURATED KETONES | Albert-Ludwigs-Universität Freiburg (DE) | 2010-01-13 | — | — | EP | disclosed |
| WO-2008138450-A1 | USE OF THE PIGD PROTEIN FOR CATALYZING 1,4-ADDITIONS OF 2-OXOALKANOATES TO ALPHA, BETA-UNSATURATED KETONES | ALBERT-LUDWIGS-UNIVERSITÄT FREIBURG (DE) | 2008-11-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100305337-A1 | Use Of The PIGD Protein For Catalyzing 1,4-Additions Of 2-Oxoalkanoates To Alpha, Beta-Unsaturated Ketones | PGD, PC, PDK4 | BRD4 4143/4885POLB 983/4885CYP2C9 631/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.