Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 12/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 10/20 | 0.44 |
| ▸ | HTR2C | P28335 | 8/20 | 0.44 |
| ▸ | DRD2 | P14416 | 5/20 | 0.43 |
| ▸ | PARP1 | P09874 | 1/20 | 0.41 |
| ▸ | KIF11 | P52732 | 1/20 | 0.41 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.40 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.40 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.40 |
| ▸ | GABRA3 | P34903 | 2/20 | 0.40 |
| ▸ | GABRA2 | P47869 | 2/20 | 0.40 |
| ▸ | CNR1 | P21554 | 1/20 | 0.39 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.39 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.38 |
| ▸ | GABRA6 | Q16445 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1173665 | 0.88 | KIF11 (0.55) | HTR2AKCNH2HTR2CDRD2PARP1 | |
| SCHEMBL19316391 | 0.86 | GABRA1 (0.44) | PARP1KIF11GABRA1GABRG2GABRB3 | |
| SCHEMBL5198654 | 0.85 | PARP1 (0.52) | HTR2AKCNH2HTR2CDRD2PARP1 | |
| SCHEMBL10293516 | 0.85 | GABRA1 (0.43) | PARP1KIF11GABRA1GABRG2GABRB3 | |
| SCHEMBL13841694 | 0.84 | PARP1 (0.38) | PARP1KIF11GABRA1GABRG2GABRB3 | |
| SCHEMBL1173816 | 0.84 | PARP1 (0.52) | HTR2AKCNH2HTR2CDRD2PARP1 | |
| SCHEMBL54140 | 0.83 | GABRA1 (0.43) | PARP1KIF11GABRA1GABRG2GABRB3 | |
| SCHEMBL4821761 | 0.82 | PARP1 (0.47) | PARP1KIF11CNR1 | |
| SCHEMBL11961347 | 0.81 | GABRA1 (0.41) | PARP1KIF11GABRA1GABRG2GABRB3 | |
| SCHEMBL14367212 | 0.80 | DVL1 (0.36) | HTR2AKCNH2HTR2CDRD2PARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7795250-B2 | Indole derivatives as antiviral agents | ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P ANGELETTI SPA (IT) | 2010-09-14 | — | — | US | disclosed |
| EP-1758857-B1 | INDOLE DERIVATIVES AS ANTIVIRAL AGENTS | ANGELETTI P IST RICHERCHE BIO (IT) | 2010-08-18 | — | — | EP | disclosed |
| US-20080261944-A1 | Indole Derivatives as Antiviral Agents | ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P ANGELETTI SPA (IT) | 2008-10-23 | — | — | US | disclosed |
| CN-1964944-A | Indole derivatives as antiviral agents | ANGELETTI P IST RICHERCHE BIO (IT) | 2007-05-16 | — | — | CN | disclosed |
| EP-1758857-A1 | INDOLE DERIVATIVES AS ANTIVIRAL AGENTS | Istituto di Richerche di Biologia Molecolare P. Angeletti S.p.A. (IT) | 2007-03-07 | — | — | EP | disclosed |
| WO-2006029912-A1 | INDOLE DERIVATIVES AS ANTIVIRAL AGENTS | ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P. ANGELETTI SPA (IT) | 2006-03-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080261944-A1 | Indole Derivatives as Antiviral Agents | IDO1, IDO2, IRF3 | HTR2A 239/4885KCNH2 2214/4885HTR2C 294/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.