Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT6 | Q8N6T7 | 2/20 | 0.52 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | KCNJ1 | P48048 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | HTR7 | P34969 | 2/20 | 0.40 |
| ▸ | HTR1A | P08908 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12006408 | 0.79 | MAPT (0.47) | SIRT6ADRB1POLBMAPTALDH1A1 | |
| SCHEMBL23444067 | 0.79 | SIRT6 (0.56) | SIRT6ADRB1POLBMAPTKCNJ1 | |
| SCHEMBL23524638 | 0.79 | SIRT6 (0.56) | SIRT6ADRB1POLBMAPTKCNJ1 | |
| SCHEMBL30958500 | 0.79 | SLC6A2 (0.37) | HRH3 | |
| SCHEMBL878133 | 0.78 | SLC6A2 (0.53) | ADRB1ALDH1A1 | |
| SCHEMBL6902076 | 0.77 | SIRT6 (0.48) | SIRT6ADRB1POLBMAPTKCNJ1 | |
| Hydrochloric Acid SCHEMBL28145406 | 0.77 | SLC6A2 (0.51) | ADRB1MAPTALDH1A1 | |
| SCHEMBL27665380 | 0.77 | SIRT6 (0.54) | SIRT6ADRB1POLBMAPTKCNJ1 | |
| SCHEMBL6606833 | 0.76 | SIRT6 (0.52) | SIRT6ADRB1POLBMAPTKCNJ1 | |
| SCHEMBL22471283 | 0.76 | ADRB1 (0.56) | SIRT6ADRB1MAPTKCNJ1KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116406259-A | Dosage form compositions comprising inhibitors of BTK and mutants thereof | 广州麓鹏制药有限公司 | 2023-07-07 | — | — | CN | disclosed |
| EP-4196124-A1 | DOSAGE FORM COMPOSITIONS COMPRISING AN INHIBITOR OF BTK AND MUTANTS THEREOF | Guangzhou Lupeng Pharmaceutical Company Ltd. (CN) | 2023-06-21 | — | — | EP | disclosed |
| WO-2022036171-A1 | DOSAGE FORM COMPOSITIONS COMPRISING AN INHIBITOR OF BTK AND MUTANTS THEREOF | NEWAVE PHARMACEUTICAL INC. (US) | 2022-02-17 | — | — | WO | disclosed |