Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT6 | Q8N6T7 | 2/20 | 0.52 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 4/20 | 0.43 |
| ▸ | HTR7 | P34969 | 2/20 | 0.43 |
| ▸ | HTR1A | P08908 | 1/20 | 0.43 |
| ▸ | KCNJ1 | P48048 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2208052 | 0.92 | SIRT6 (0.47) | SIRT6ADRB1MAPTHTR7HTR1A | |
| SCHEMBL5827683 | 0.86 | HTR1A (0.43) | MAPTHTR7HTR1AALDH1A1 | |
| SCHEMBL29310316 | 0.83 | SLC6A2 (0.53) | SIRT6ADRB1MAPTHTR7HTR1A | |
| SCHEMBL23524638 | 0.82 | SIRT6 (0.56) | SIRT6ADRB1MAPTHTR7HTR1A | |
| SCHEMBL23444067 | 0.82 | SIRT6 (0.56) | SIRT6ADRB1MAPTHTR7HTR1A | |
| SCHEMBL644545 | 0.79 | SLC6A2 (0.54) | ADRB1MAPTHTR7ALDH1A1 | |
| SCHEMBL15828757 | 0.79 | MAPT (0.49) | SIRT6ADRB1MAPTALDH1A1POLB | |
| Hydrochloric Acid SCHEMBL5793498 | 0.78 | SLC6A2 (0.53) | ADRB1MAPTHTR7ALDH1A1 | |
| Bromide SCHEMBL27797303 | 0.78 | SLC6A2 (0.53) | ADRB1MAPTHTR7ALDH1A1 | |
| Bicarbonate SCHEMBL11620060 | 0.77 | SLC6A2 (0.49) | ADRB1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101827848-B | 2- [ (2- { phenylamino } -1H-pyrrolo [2,3-d ] pyrimidin-4-yl) amino ] benzamide derivatives as IGF-1R inhibitors for the treatment of cancer | GLAXOSMITHKLINE LLC | 2012-11-07 | — | — | CN | disclosed |
| CN-101827848-A | 2- [ (2- { phenylamino } -1H-pyrrolo [2,3-d ] pyrimidin-4-yl) amino ] benzamide derivatives as IGF-1R inhibitors for the treatment of cancer | SMITHKLINE BEECHAM CORP | 2010-09-08 | — | — | CN | disclosed |
| EP-0729455-B1 | INDOLE-DERIVED AZYLPIPERAZINES AS LIGANDS FOR 5HT1-LIKE RECEPTORS 5HT1B AND 5HT1D | PF MEDICAMENT (FR) | 2004-09-08 | — | — | EP | disclosed |
| EP-0729455-A1 | INDOLE-DERIVED AZYLPIPERAZINES AS LIGANDS FOR 5HT1-LIKE RECEPTORS 5HT1B AND 5HT1D | PIERRE FABRE MEDICAMENT (FR) | 1996-09-04 | — | — | EP | disclosed |
| WO-1995014004-A1 | INDOLE-DERIVED AZYLPIPERAZINES AS LIGANDS FOR 5HT1-LIKE RECEPTORS 5HT1B AND 5HT1D | PIERRE FABRE MEDICAMENT (FR) | 1995-05-26 | — | — | WO | disclosed |