Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | GLA | P06280 | 1/20 | 0.30 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29080904 | 0.80 | SMN1; SMN2 (0.30) | — | |
| SCHEMBL18372754 | 0.79 | PKM (0.33) | PKMKDM4EALDH1A1GLAGAA | |
| SCHEMBL18372797 | 0.74 | PKM (0.40) | PKMKDM4EALDH1A1 | |
| SCHEMBL18372933 | 0.73 | PKM (0.33) | PKM | |
| SCHEMBL29080903 | 0.73 | NPC1 (0.33) | ALDH1A1 | |
| SCHEMBL22887875 | 0.72 | PKM (0.36) | PKMKDM4EALDH1A1 | |
| SCHEMBL18377756 | 0.72 | PKM (0.36) | PKMKDM4EALDH1A1 | |
| SCHEMBL18372922 | 0.71 | — | — | |
| SCHEMBL18367167 | 0.71 | — | — | |
| SCHEMBL18366857 | 0.69 | KDM4E (0.33) | KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111269221-B | Bicyclic lactams and methods of use thereof | 豪夫迈·罗氏有限公司 | 2023-09-26 | — | — | CN | disclosed |