Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | CASP1 | P29466 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29080931 | 0.86 | POLB (0.34) | MAPTKMT2ARIPK1 | |
| SCHEMBL18366416 | 0.81 | ALDH1A1 (0.35) | NPC1ALDH1A1TP53HPGDCASP1 | |
| SCHEMBL30587638 | 0.81 | ALDH1A1 (0.35) | NPC1ALDH1A1TP53HPGDCASP1 | |
| SCHEMBL18367374 | 0.78 | NPC1 (0.32) | NPC1ALDH1A1TP53HPGDCASP1 | |
| SCHEMBL29080908 | 0.77 | RIPK1 (0.44) | NPC1ALDH1A1TP53HPGDCASP1 | |
| SCHEMBL18366601 | 0.77 | RIPK1 (0.41) | NPC1ALDH1A1TP53HPGDCASP1 | |
| SCHEMBL29080904 | 0.76 | SMN1; SMN2 (0.30) | — | |
| SCHEMBL18372625 | 0.75 | RIPK1 (0.34) | NPC1ALDH1A1TP53HPGDCASP1 | |
| SCHEMBL30587561 | 0.75 | NPC1 (0.31) | NPC1ALDH1A1TP53HPGDCASP1 | |
| SCHEMBL18367169 | 0.75 | NPC1 (0.31) | NPC1ALDH1A1TP53HPGDCASP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111269221-B | Bicyclic lactams and methods of use thereof | 豪夫迈·罗氏有限公司 | 2023-09-26 | — | — | CN | disclosed |