SCHEMBL2908265

SCHEMBL2908265

CN1CCCN(S(=O)(=O)c2cccc3cnccc23)CC1

nearest known ligand 0.67

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ROCK2 O75116 13/20 0.67
ROCK1 Q13464 10/20 0.67
CYP3A4 P08684 4/20 0.67
PRKD3 O94806 3/20 0.67
PRKCG P05129 3/20 0.67
PRKCB P05771 3/20 0.67
PRKCA P17252 3/20 0.67
PRKCH P24723 3/20 0.67
PRKCI P41743 3/20 0.67
PRKCE Q02156 3/20 0.67
PRKCQ Q04759 3/20 0.67
PRKCZ Q05513 3/20 0.67
PRKCD Q05655 3/20 0.67
PRKD1 Q15139 3/20 0.67
ADORA3 P0DMS8 2/20 0.67
PRKACA P17612 2/20 0.67
PRKACG P22612 2/20 0.67
PRKACB P22694 2/20 0.67
CCR2 P41597 2/20 0.67
CYP2D6 P10635 2/20 0.67

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2902584 0.95 CYP3A4 (0.72) ROCK2ROCK1CYP3A4PRKD3PRKCG
SCHEMBL29770053 0.92 ROCK2 (0.77) ROCK2ROCK1CYP3A4PRKD3PRKCG
SCHEMBL10988523 0.88 ROCK2 (0.79) ROCK2ROCK1CYP3A4PRKD3PRKCG
SCHEMBL26584304 0.87 ROCK2 (0.77) ROCK2ROCK1CYP3A4PRKD3PRKCG
SCHEMBL10985139 0.87 ROCK2 (0.77) ROCK2ROCK1CYP3A4PRKD3PRKCG
SCHEMBL6916059 0.87 ROCK2 (0.77) ROCK2ROCK1CYP3A4PRKD3PRKCG
SCHEMBL14372232 0.87 PRKD3 (0.62) ROCK2ROCK1CYP3A4PRKD3PRKCG
SCHEMBL21688438 0.87 ROCK2 (0.66) ROCK2ROCK1CYP3A4PRKD3PRKCG
Hydrochloric Acid SCHEMBL9617961 0.86 ROCK2 (0.77) ROCK2ROCK1CYP3A4PRKD3PRKCG
SCHEMBL14818897 0.85 ROCK2 (0.67) ROCK2ROCK1CYP3A4PRKD3PRKCG

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1479386-A1 Use of isoquinoline-derivatives for treating and preventing pigmentary disorders Switch Biotech Aktiengesellschaft (DE) 2004-11-24 EP claimed
US-20230330101-A1 ORAL FORMULATIONS OF FASUDIL WITH ION EXCHANGE RESIN WOOLSEY PHARMACEUTICALS, INC. 2023-10-19 US disclosed
US-20230330100-A1 TASTE-MASKING ORAL FORMULATIONS OF FASUDIL WOOLSEY PHARMACEUTICALS, INC. 2023-10-19 US disclosed
US-11548861-B2 Drugs and compositions for the treatment of ocular disorders Graybug Vision, Inc. (US) 2023-01-10 US disclosed
WO-2021024041-A1 CONTROLLED RELEASE DRUG DIMERS RIPPLE THERAPEUTICS CORPORATION (CA) 2021-02-11 WO disclosed
EP-0956865-B2 MEDICINES COMPRISING Rho KINASE INHIBITOR MITSUBISHI TANABE PHARMA CORP (JP) 2010-08-18 EP disclosed
US-20100048890-A1 CONJUGATED SMALL MOLECULES DISCOVERX CORPORATION 2010-02-25 US disclosed
US-20090036465-A1 COMBINATION THERAPY FOR PULMONARY ARTERIAL HYPERTENSION UNITED THERAPEUTICS CORPORATION 2009-02-05 US disclosed
WO-2008049000-A2 COMBINATION THERAPY FOR PULMONARY ARTERIAL HYPERTENSION UNITED THERAPEUTICS CORPORATION (US) 2008-04-24 WO disclosed
EP-0956865-B1 MEDICINES COMPRISING Rho KINASE INHIBITOR MITSUBISHI PHARMA CORP (JP) 2007-04-18 EP disclosed
US-20030134775-A1 Pharmaceutical agent containing Rho kinase inhibitor UEHATA MASAYOSHI (JP) 2003-07-17 US disclosed
US-6451825-B1 FOR THERAPY OF HYPERTENSION, A THERAPEUTIC AGENT OF ANGINA PECTORIS, A SUPPRESSIVE AGENT OF CEREBROVASCULAR CONTRACTION, ASTHMA, PERIPHERAL CIRCULATION DISORDER, AS PROPHYLACTIC AGENT OF IMMATURE BIRTH, A THERAPEUTIC AGENT OF ARTERIOSCLEROSIS MITSUBISHI PHARMA CORPORATION (JP) 2002-09-17 US disclosed
US-20020032148-A1 Pharmaceutical agent containing Rho kinase inhibitor MITSUBISHI PHARMA CORPORATION (JP) 2002-03-14 US disclosed
US-6218410-B1 ADMINISTERING A PHARMACEUTICALLY EFFECTIVE AMOUNT OF A RHO KINASE INHIBITOR COMPRISING AMIDE COMPOUND FOR INHIBITING RHO KINASE YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) 2001-04-17 US disclosed
EP-0956865-A1 MEDICINES COMPRISING Rho KINASE INHIBITOR YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) 1999-11-17 EP disclosed
US-5747507-A MYOCARDIAL DISEASE ASAHI KASEI KOGYO KABUSHIKI KAISHA (JP) 1998-05-05 US disclosed
EP-0654266-A1 CARDIAC PROTECTIVE Asahi Kasei Kogyo Kabushiki Kaisha (JP) 1995-05-24 EP disclosed
EP-0187371-B1 SUBSTITUTED ISOQUINOLINESULFONYL COMPOUNDS Asahi Kasei Kogyo Kabushiki Kaisha (JP) 1991-06-19 EP disclosed
US-4678783-A CARDIOVASCULAR DISORDERS, HYPOTENSIVES, ARTERIOSCLEROSIS ASAHI KASEI KOGYO KABUSHIKI KAISHA (JP) 1987-07-07 US disclosed
EP-0187371-A2 Substituted isoquinolinesulfonyl compounds Asahi Kasei Kogyo Kabushiki Kaisha (JP) 1986-07-16 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100048890-A1 CONJUGATED SMALL MOLECULES ERBB2, ALK, ACP1 ROCK2 2356/4885ROCK1 2223/4885CYP3A4 4556/4885
US-20230330101-A1 ORAL FORMULATIONS OF FASUDIL WITH ION EXCHANGE RESIN MOK, ROCK1, ROCK2 ROCK2 3/4885ROCK1 2/4885CYP3A4 2244/4885
US-20230330100-A1 TASTE-MASKING ORAL FORMULATIONS OF FASUDIL ROCK1, TAS2R42, MOK ROCK2 4/4885ROCK1 1/4885CYP3A4 2719/4885
US-11548861-B2 Drugs and compositions for the treatment of ocular disorders PDE6C, PDE6A, PDE6D ROCK2 400/4885ROCK1 197/4885CYP3A4 2887/4885
US-20030134775-A1 Pharmaceutical agent containing Rho kinase inhibitor ROCK1, RHOA, ARHGDIA ROCK2 4/4885ROCK1 1/4885CYP3A4 3462/4885
US-20090036465-A1 COMBINATION THERAPY FOR PULMONARY ARTERIAL HYPERTENSION ROCK1, ROCK2, RHOA ROCK2 2/4885ROCK1 1/4885CYP3A4 4667/4885
US-20020032148-A1 Pharmaceutical agent containing Rho kinase inhibitor ROCK1, RHOA, ARHGDIA ROCK2 4/4885ROCK1 1/4885CYP3A4 3462/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.