Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 1/20 | 0.52 |
| ▸ | KARS1 | Q15046 | 6/20 | 0.45 |
| ▸ | NNMT | P40261 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 3/20 | 0.43 |
| ▸ | RAB9A | P51151 | 3/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | SORT1 | Q99523 | 2/20 | 0.42 |
| ▸ | SYK | P43405 | 2/20 | 0.42 |
| ▸ | AURKA | O14965 | 2/20 | 0.42 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.42 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.42 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.42 |
| ▸ | ABL1 | P00519 | 1/20 | 0.42 |
| ▸ | LCK | P06239 | 1/20 | 0.42 |
| ▸ | FYN | P06241 | 1/20 | 0.42 |
| ▸ | IGF1R | P08069 | 1/20 | 0.42 |
| ▸ | LTK | P29376 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30378912 | 0.76 | JAK2 (0.47) | JAK2KARS1NNMTNPC1RAB9A | |
| SCHEMBL2912518 | 0.74 | KDR (0.57) | KARS1NPC1RAB9APOLBKMT2A | |
| SCHEMBL31247536 | 0.74 | JAK2 (0.54) | JAK2AURKARPS6KB1AURKBMAPK8 | |
| SCHEMBL29084261 | 0.72 | JAK2 (0.46) | JAK2KARS1NPC1RAB9AKMT2A | |
| SCHEMBL28418739 | 0.72 | GAA (0.58) | JAK2NNMTNPC1RAB9APOLB | |
| SCHEMBL901655 | 0.72 | KARS1 (0.70) | JAK2KARS1NPC1RAB9AKMT2A | |
| SCHEMBL30923290 | 0.71 | JAK2 (0.48) | JAK2KARS1NNMTNPC1RAB9A | |
| SCHEMBL27819532 | 0.71 | NPC1 (0.45) | KARS1NPC1RAB9APOLBKMT2A | |
| SCHEMBL9749752 | 0.71 | NR3C2 (0.64) | NPC1RAB9AKMT2APKMSMN1; SMN2 | |
| SCHEMBL2869562 | 0.70 | KARS1 (0.55) | JAK2KARS1NPC1RAB9AKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111936486-B | Heterocyclic compounds comprising pyridine as modulators of IL-12, IL-23 and/or IFN alpha responses | 百时美施贵宝公司 | 2023-09-22 | — | — | CN | disclosed |