Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 7/20 | 0.41 |
| ▸ | RAB9A | P51151 | 7/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | TYK2 | P29597 | 2/20 | 0.41 |
| ▸ | FDPS | P14324 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.40 |
| ▸ | TP53 | P04637 | 3/20 | 0.40 |
| ▸ | PKM | P14618 | 2/20 | 0.40 |
| ▸ | KARS1 | Q15046 | 2/20 | 0.40 |
| ▸ | SYK | P43405 | 2/20 | 0.40 |
| ▸ | JAK1 | P23458 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.39 |
| ▸ | ABL1 | P00519 | 1/20 | 0.39 |
| ▸ | LCK | P06239 | 1/20 | 0.39 |
| ▸ | FYN | P06241 | 1/20 | 0.39 |
| ▸ | IGF1R | P08069 | 1/20 | 0.39 |
| ▸ | LTK | P29376 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30379305 | 0.92 | JAK2 (0.43) | JAK2NPC1RAB9AMEN1KMT2A | |
| SCHEMBL29084254 | 0.83 | TYK2 (0.51) | JAK2NPC1RAB9ATYK2PKM | |
| SCHEMBL29084264 | 0.83 | ALDH1A1 (0.46) | SYKSORT1ALDH1A1 | |
| SCHEMBL30378912 | 0.79 | JAK2 (0.47) | JAK2NPC1RAB9AMEN1KMT2A | |
| SCHEMBL28411950 | 0.78 | SYK (0.43) | JAK2TYK2SYKJAK1KCNH2 | |
| SCHEMBL29084257 | 0.77 | SYK (0.39) | JAK2TYK2SYKKCNH2MAP4K4 | |
| SCHEMBL28413940 | 0.76 | NNMT (0.43) | JAK2TYK2SYKJAK1KCNH2 | |
| SCHEMBL28477215 | 0.75 | ILK (0.49) | JAK2MEN1KMT2ATYK2TP53 | |
| SCHEMBL29084256 | 0.75 | SYK (0.57) | JAK2RAB9ATYK2SYKJAK1 | |
| SCHEMBL2912518 | 0.74 | KDR (0.57) | NPC1RAB9AMEN1KMT2AFDPS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111936486-B | Heterocyclic compounds comprising pyridine as modulators of IL-12, IL-23 and/or IFN alpha responses | 百时美施贵宝公司 | 2023-09-22 | — | — | CN | disclosed |