Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | GAA | P10253 | 3/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | HTT | P42858 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | GFER | P55789 | 1/20 | 0.35 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.34 |
| ▸ | AURKA | O14965 | 1/20 | 0.34 |
| ▸ | ABL1 | P00519 | 1/20 | 0.34 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.34 |
| ▸ | LCK | P06239 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2913685 | 0.94 | MAPT (0.38) | LMNAALDH1A1GAAKDM4EMEN1 | |
| SCHEMBL2938540 | 0.92 | MAPT (0.41) | LMNAGAAMEN1HTTKMT2A | |
| SCHEMBL2907284 | 0.92 | MEN1 (0.37) | THRBLMNAALDH1A1GAACYP1A2 | |
| Hydrochloric Acid SCHEMBL2911758 | 0.79 | MAPT (0.42) | LMNAALDH1A1GAACYP1A2KDM4E | |
| SCHEMBL2947795 | 0.75 | ADCY1 (0.44) | LMNAKDM4EMEN1KMT2ATSHR | |
| SCHEMBL4036180 | 0.74 | PTGS2 (0.37) | ALDH1A1GAACYP1A2KDM4EMEN1 | |
| Hydrochloric Acid SCHEMBL4039957 | 0.72 | PTGS2 (0.36) | ALDH1A1GAACYP1A2KDM4EMEN1 | |
| SCHEMBL2940746 | 0.70 | KDM4E (0.44) | ALDH1A1CYP1A2KDM4EMEN1HTT | |
| SCHEMBL2913204 | 0.69 | ADCY1 (0.39) | LMNAGAAKDM4EMAPTRAB9A | |
| SCHEMBL13791048 | 0.63 | PTGS2 (0.41) | LMNAALDH1A1KDM4EMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 38 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1481679-B1 | ANTIDEPRESSANT | TAKEDA PHARMACEUTICAL (JP) | 2010-08-25 | — | — | EP | claimed |
| EP-2069229-A1 | METHOD FOR NANOPARTICLE SURFACE MODIFICATION | 3M Innovative Properties Company (US) | 2009-06-17 | — | — | EP | claimed |
| EP-1323716-B1 | PROMOTERS FOR THE PROLIFERATION AND DIFFERENTIATION OF STEM CELLS AND/OR NEURON PRECURSOR CELLS | TAKEDA PHARMACEUTICAL (JP) | 2009-01-14 | — | — | EP | claimed |
| US-20090012081-A1 | Agents for promoting the proliferation or differentiation of stem cells or neural progenitor cells | TAKEDA PHARMACEUTICAL COMPANY LTD. (JP) | 2009-01-08 | — | — | US | claimed |
| US-7456162-B2 | Benzofuran derivatives, their production and use | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2008-11-25 | — | — | US | claimed |
| US-20080069887-A1 | Method for nanoparticle surface modification | 3M INNOVATIVE PROPERTIES COMPANY | 2008-03-20 | — | — | US | claimed |
| WO-2008033718-A1 | METHOD FOR NANOPARTICLE SURFACE MODIFICATION | 3M INNOVATIVE PROPERTIES COMPANY (US) | 2008-03-20 | — | — | WO | claimed |
| US-20060241168-A1 | Antidepressant | OHKAWA SHIGENORI | 2006-10-26 | — | — | US | claimed |
| US-20050187238-A1 | Benzofuran derivatives, their production and use | OHKAWA SHIGENORI (JP) | 2005-08-25 | — | — | US | claimed |
| CN-1638763-A | antidepressants | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 2005-07-13 | — | — | CN | claimed |
| EP-1136477-B1 | BENZOFURAN DERIVATIVES, PROCESS FOR THE PREPARATION OF THE SAME AND USES THEREOF | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 2004-03-10 | — | — | EP | claimed |
| US-20040034049-A1 | Promoters for the proliferation and differentiation of stem cells and/or neuron precursor cells | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2004-02-19 | — | — | US | claimed |
| EP-1323716-A1 | PROMOTERS FOR THE PROLIFERATION AND DIFFERENTIATION OF STEM CELLS AND/OR NEURON PRECURSOR CELLS | Takeda Chemical Industries, Ltd. (JP) | 2003-07-02 | — | — | EP | claimed |
| US-20020160996-A1 | Benzofuran derivatives, their production and use | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2002-10-31 | — | — | US | claimed |
| EP-1136477-A1 | BENZOFURAN DERIVATIVES, PROCESS FOR THE PREPARATION OF THE SAME AND USES THEREOF | Takeda Chemical Industries, Ltd. (JP) | 2001-09-26 | — | — | EP | claimed |
| EP-1481679-B1 | ANTIDEPRESSANT | TAKEDA PHARMACEUTICAL (JP) | 2010-08-25 | — | — | EP | disclosed |
| US-7750037-B2 | Antidepressant | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-07-06 | — | — | US | disclosed |
| US-6479536-B1 | Benzofuran derivatives, process for the preparation of the same and uses thereof | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2002-11-12 | — | — | US | disclosed |
| US-20020160996-A1 | Benzofuran derivatives, their production and use | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2002-10-31 | — | — | US | disclosed |
| EP-1136477-A1 | BENZOFURAN DERIVATIVES, PROCESS FOR THE PREPARATION OF THE SAME AND USES THEREOF | Takeda Chemical Industries, Ltd. (JP) | 2001-09-26 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060241168-A1 | Antidepressant | AKT1S1, AKT1, AKT2 | THRB 171/4885LMNA 1435/4885ALDH1A1 3081/4885 |
| US-20090012081-A1 | Agents for promoting the proliferation or differentiation of stem cells or neural progenitor cells | NES, MKI67, CCNO | THRB 753/4885LMNA 1938/4885ALDH1A1 359/4885 |
| US-20050187238-A1 | Benzofuran derivatives, their production and use | WDR1, WDR82, CBR1 | THRB 1851/4885LMNA 1075/4885ALDH1A1 735/4885 |
| US-20080069887-A1 | Method for nanoparticle surface modification | MGMT, AS3MT, NCL | THRB 4117/4885LMNA 2919/4885ALDH1A1 913/4885 |
| US-20040034049-A1 | Promoters for the proliferation and differentiation of stem cells and/or neuron precursor cells | NES, HAT1, PROX1 | THRB 657/4885LMNA 1890/4885ALDH1A1 311/4885 |
| US-20020160996-A1 | Benzofuran derivatives, their production and use | PARK7, WDR1, WHR1 | THRB 2234/4885LMNA 972/4885ALDH1A1 311/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.