Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 9/20 | 0.56 |
| ▸ | WDR77 | Q9BQA1 | 9/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | HPGD | P15428 | 1/20 | 0.54 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.50 |
| ▸ | BCL9 | O00512 | 2/20 | 0.50 |
| ▸ | CTNNB1 | P35222 | 2/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21138877 | 0.89 | ALDH1A1 (0.57) | PRMT5WDR77ALDH1A1LMNAHPGD | |
| SCHEMBL29087342 | 0.86 | SMN1; SMN2 (0.59) | PRMT5WDR77ALDH1A1LMNAHPGD | |
| SCHEMBL4002382 | 0.84 | CHRM4 (0.58) | PRMT5WDR77ALDH1A1POLBHSD11B1 | |
| SCHEMBL31233182 | 0.81 | ALDH1A1 (0.59) | ALDH1A1LMNAHPGDHIF1APOLB | |
| SCHEMBL27878990 | 0.80 | ALDH1A1 (0.62) | ALDH1A1LMNAHPGDHIF1APOLB | |
| SCHEMBL3312540 | 0.80 | ALDH1A1 (0.62) | ALDH1A1LMNAHPGDHIF1APOLB | |
| SCHEMBL6359096 | 0.79 | ALDH1A1 (0.56) | PRMT5ALDH1A1LMNAHPGDHIF1A | |
| SCHEMBL21159622 | 0.79 | BRD4 (0.61) | ALDH1A1LMNAHPGDHIF1AHSD11B1 | |
| SCHEMBL31198901 | 0.78 | PDE4B (0.54) | PRMT5WDR77ALDH1A1POLBBCL9 | |
| SCHEMBL28351668 | 0.78 | PRMT5 (0.60) | PRMT5WDR77ALDH1A1LMNAPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2077719-A2 | PIPERIDINE AND PYRROLIDINE BETA-SECRETASE INHIBITORS FOR THE TREATMENT OF ALZHEIMER'S DISEASE | Merck and Co., Inc. (US) | 2009-07-15 | — | — | EP | disclosed |
| WO-2008036316-A2 | PIPERIDINE AND PYRROLIDINE BETA-SECRETASE INHIBITORS FOR THE TREATMENT OF ALZHEIMER'S DISEASE | MERCK & CO., INC. (US) | 2008-03-27 | — | — | WO | disclosed |