Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2BTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3MPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PPARGSLC6A2SLC6A3SLC6A4SMOTYK2pol
The experimentally established mechanism targets of Maleic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.53 |
| ▸ | TP53 | P04637 | 2/20 | 0.53 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.53 |
| ▸ | EGLN3 | Q9H6Z9 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.52 |
| ▸ | HTT | P42858 | 2/20 | 0.52 |
| ▸ | GAA | P10253 | 2/20 | 0.52 |
| ▸ | NPC1 | O15118 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | MITF | O75030 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | NLRP1 | Q9C000 | 1/20 | 0.40 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Biphenyl SCHEMBL28905684 | 0.97 | HTT (0.56) | TSHRTP53EGLN1EGLN3SMN1; SMN2 | |
| Maleic Acid SCHEMBL28396018 | 0.97 | HTT (0.56) | TSHRTP53EGLN1EGLN3SMN1; SMN2 | |
| Fumaric Acid SCHEMBL29080582 | 0.97 | HTT (0.56) | TSHRTP53EGLN1EGLN3SMN1; SMN2 | |
| Biphenyl SCHEMBL4308447 | 0.97 | HTT (0.56) | TSHRTP53EGLN1EGLN3SMN1; SMN2 | |
| Fumaric Acid SCHEMBL930661 | 0.92 | TSHR (0.50) | TSHRTP53EGLN1EGLN3SMN1; SMN2 | |
| Fumaric Acid SCHEMBL930663 | 0.92 | TSHR (0.50) | TSHRTP53EGLN1EGLN3SMN1; SMN2 | |
| Fumaric Acid SCHEMBL27442919 | 0.83 | SMN1; SMN2 (0.44) | TSHRTP53EGLN1EGLN3SMN1; SMN2 | |
| Maleic Acid SCHEMBL27738908 | 0.83 | SMN1; SMN2 (0.44) | TSHRTP53EGLN1EGLN3SMN1; SMN2 | |
| Fumaric Acid SCHEMBL8901877 | 0.81 | HTT (0.47) | TSHRTP53EGLN1EGLN3SMN1; SMN2 | |
| Fumaric Acid SCHEMBL8901874 | 0.81 | HTT (0.47) | TSHRTP53EGLN1EGLN3SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118284651-A | Heat insulating sheet, sheet for battery module, and battery module | 日本瑞翁株式会社 | 2024-07-02 | — | — | CN | disclosed |
| CN-116917359-A | Acrylic rubber, rubber composition, and crosslinked rubber | 日本瑞翁株式会社 | 2023-10-20 | — | — | CN | disclosed |