Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2BTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3MPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PPARGSLC6A2SLC6A3SLC6A4SMOTYK2pol
The experimentally established mechanism targets of Biphenyl. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.56 |
| ▸ | GAA | P10253 | 2/20 | 0.56 |
| ▸ | NPC1 | O15118 | 1/20 | 0.56 |
| ▸ | TSHR | P16473 | 2/20 | 0.50 |
| ▸ | TP53 | P04637 | 2/20 | 0.50 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.50 |
| ▸ | EGLN3 | Q9H6Z9 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | MITF | O75030 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | NLRP1 | Q9C000 | 1/20 | 0.43 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Maleic Acid SCHEMBL28396018 | 1.00 | HTT (0.56) | HTTSMN1; SMN2GAANPC1TSHR | |
| Biphenyl SCHEMBL28905684 | 1.00 | HTT (0.56) | HTTSMN1; SMN2GAANPC1TSHR | |
| Fumaric Acid SCHEMBL29080582 | 1.00 | HTT (0.56) | HTTSMN1; SMN2GAANPC1TSHR | |
| Maleic Acid SCHEMBL29090331 | 0.97 | TSHR (0.53) | HTTSMN1; SMN2GAANPC1TSHR | |
| Fumaric Acid SCHEMBL930661 | 0.89 | TSHR (0.50) | HTTSMN1; SMN2GAANPC1TSHR | |
| Fumaric Acid SCHEMBL930663 | 0.89 | TSHR (0.50) | HTTSMN1; SMN2GAANPC1TSHR | |
| Fumaric Acid SCHEMBL8901874 | 0.84 | HTT (0.47) | HTTSMN1; SMN2GAANPC1TSHR | |
| Fumaric Acid SCHEMBL8901877 | 0.84 | HTT (0.47) | HTTSMN1; SMN2GAANPC1TSHR | |
| Biphenyl SCHEMBL2169497 | 0.82 | ALDH1A1 (0.57) | HTTSMN1; SMN2NPC1TSHRALDH1A1 | |
| Bicarbonate SCHEMBL10775900 | 0.82 | ALDH1A1 (0.57) | HTTSMN1; SMN2NPC1TSHRALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106947372-B | Coating composition comprising polyisocyanate-extended NH functional prepolymer | 涂层国外知识产权有限公司 | 2021-01-01 | — | — | CN | disclosed |
| US-20090267489-A1 | GAS BARRIER THIN FILM LAMINATE, GAS BARRIER RESIN SUBSTRATE AND ORGANIC EL DEVICE | KONICA MINOLTA HOLDINGS, INC. (JP) | 2009-10-29 | — | — | US | disclosed |
| EP-0987282-B1 | Acrylic monomer composition, acrylic copolymer, and heat resistant resin | NIPPON CATALYTIC CHEM IND (JP) | 2006-04-12 | — | — | EP | disclosed |
| US-6423806-B1 | Acrylic monomer composition, acrylic copolymer, and heat resistant resin | NIPPON SHOKUBAI CO., LTD. (JP) | 2002-07-23 | — | — | US | disclosed |
| EP-0987282-A2 | Acrylic monomer composition, acrylic copolymer, and heat resistant resin | Nippon Shokubai Co., Ltd. (JP) | 2000-03-22 | — | — | EP | disclosed |