Butoconazole

Butoconazole

SCHEMBL29091982

Cl.Clc1ccc(CCC(Cn2ccnc2)Sc2c(Cl)cccc2Cl)cc1

nearest known ligand 0.98

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ERG11

The experimentally established mechanism targets of Butoconazole. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 3/20 0.98
CYP3A4 P08684 3/20 0.98
CYP2D6 P10635 3/20 0.98
CYP2C9 P11712 3/20 0.98
CYP2C19 P33261 3/20 0.98
ALOX15 P16050 2/20 0.98
TDP1 Q9NUW8 2/20 0.98
NR1I2 O75469 2/20 0.98
NR3C1 P04150 2/20 0.98
ADORA3 P0DMS8 2/20 0.98
ADRA2B P18089 2/20 0.98
CHRM3 P20309 2/20 0.98
AGTR1 P30556 2/20 0.98
OPRK1 P41145 2/20 0.98
SLC6A3 Q01959 2/20 0.98
PDE4D Q08499 2/20 0.98
KCNH2 Q12809 2/20 0.98
ALDH1A1 P00352 1/20 0.98
LMNA P02545 1/20 0.98
TP53 P04637 1/20 0.98

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Butoconazole SCHEMBL44238 0.99 CYP1A2 (1.00) CYP1A2CYP3A4CYP2D6CYP2C9CYP2C19
Butoconazole SCHEMBL44239 0.99 CYP1A2 (1.00) CYP1A2CYP3A4CYP2D6CYP2C9CYP2C19
Butoconazole SCHEMBL44237 0.99 CYP1A2 (1.00) CYP1A2CYP3A4CYP2D6CYP2C9CYP2C19
Butoconazole SCHEMBL41395 0.91 L3MBTL1 (1.00) CYP1A2CYP3A4CYP2D6CYP2C9CYP2C19
Butoconazole SCHEMBL41394 0.91 L3MBTL1 (1.00) CYP1A2CYP3A4CYP2D6CYP2C9CYP2C19
SCHEMBL14340044 0.91 CYP1A2 (0.85) CYP1A2CYP3A4CYP2D6CYP2C9CYP2C19
Butoconazole SCHEMBL28464029 0.90 ALDH1A1 (0.83) CYP1A2CYP3A4CYP2D6CYP2C9CYP2C19
SCHEMBL11633890 0.90 ALDH1A1 (0.83) CYP1A2CYP3A4CYP2D6CYP2C9CYP2C19
SCHEMBL11442840 0.90 ALDH1A1 (0.83) CYP1A2CYP3A4CYP2D6CYP2C9CYP2C19
SCHEMBL11633431 0.90 ALDH1A1 (0.83) CYP1A2CYP3A4CYP2D6CYP2C9CYP2C19

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-116940351-A Prodrug compositions and methods of treatment 阿奎斯蒂弗医疗股份有限公司 2023-10-24 CN disclosed