Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Butoconazole. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 1.00 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.84 |
| ▸ | TDP1 | Q9NUW8 | 5/20 | 0.84 |
| ▸ | LMNA | P02545 | 4/20 | 0.84 |
| ▸ | TP53 | P04637 | 4/20 | 0.84 |
| ▸ | HIF1A | Q16665 | 4/20 | 0.84 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.84 |
| ▸ | TSHR | P16473 | 2/20 | 0.84 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.84 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.84 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.84 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.84 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.84 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.84 |
| ▸ | ESR1 | P03372 | 1/20 | 0.84 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.84 |
| ▸ | PGR | P06401 | 1/20 | 0.84 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.84 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.84 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.84 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Butoconazole SCHEMBL41395 | 1.00 | L3MBTL1 (1.00) | L3MBTL1CYP3A4TDP1LMNATP53 | |
| Butoconazole SCHEMBL44239 | 0.92 | CYP1A2 (1.00) | L3MBTL1CYP3A4TDP1LMNATP53 | |
| Butoconazole SCHEMBL44238 | 0.92 | CYP1A2 (1.00) | L3MBTL1CYP3A4TDP1LMNATP53 | |
| Butoconazole SCHEMBL44237 | 0.92 | CYP1A2 (1.00) | L3MBTL1CYP3A4TDP1LMNATP53 | |
| Butoconazole SCHEMBL29091982 | 0.91 | CYP1A2 (0.98) | L3MBTL1CYP3A4TDP1LMNATP53 | |
| Nitric Acid SCHEMBL11152344 | 0.88 | L3MBTL1 (0.78) | L3MBTL1CYP3A4TDP1LMNATP53 | |
| Butoconazole SCHEMBL28464029 | 0.87 | ALDH1A1 (0.83) | L3MBTL1CYP3A4TDP1LMNATP53 | |
| Butoconazole SCHEMBL15532755 | 0.87 | L3MBTL1 (0.76) | L3MBTL1CYP3A4TDP1LMNATP53 | |
| SCHEMBL14340044 | 0.84 | CYP1A2 (0.85) | L3MBTL1CYP3A4TDP1LMNATP53 | |
| Nitric Acid SCHEMBL11308755 | 0.84 | L3MBTL1 (0.72) | L3MBTL1CYP3A4TDP1LMNATP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 2659 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240282425-A1 | AUTHENTICATION METHODS AND SYSTEMS FOR DISPENSED PRESCRIPTIONS | LOW GORDON KEITH (US) | 2024-08-22 | — | — | US | claimed |
| EP-4232004-A1 | FRACTAL FORMULATIONS | Nanogyre Sprl (BE) | 2023-08-30 | — | — | EP | claimed |
| CN-110623915-B | Butoconazole nitrate vaginal expansion suppository and preparation method and application thereof | 哈尔滨欧替药业有限公司 | 2023-05-09 | — | — | CN | claimed |
| CN-115362006-A | Personal care compositions, methods of using the same and improvements in deposition | 巴斯夫欧洲公司 | 2022-11-18 | — | — | CN | claimed |
| CN-113559264-A | Methods of treating microbial infections including mastitis | 罗达制药公司 | 2021-10-29 | — | — | CN | claimed |
| CN-113144197-A | Method of treating topical microbial infections | 罗达制药公司 | 2021-07-23 | — | — | CN | claimed |
| WO-2021078412-A1 | FRACTAL FORMULATIONS | MESSADEK JALLAL (BE) | 2021-04-29 | — | — | WO | claimed |
| CN-110218742-B | Reagent for virus infected cell and application thereof | 北京双因生物科技有限公司 | 2021-03-02 | — | — | CN | claimed |
| US-10736854-B2 | Nanocrystals, compositions, and methods that aid particle transport in mucus | THE JOHNS HOPKINS UNIVERSITY (US) | 2020-08-11 | — | — | US | claimed |
| EP-3348272-B1 | COMPOSITION FOR USE IN THE TREATMENT OF PARONYCHIA | VELOCE BIOPHARMA LLC (US) | 2020-06-24 | — | — | EP | claimed |
| EP-1130964-A1 | THERAPEUTIC ANTI-FUNGAL NAIL PREPARATION | Astan, Inc. (US) | 2001-09-12 | — | — | EP | claimed |
| US-6159977-A | Therapeutic anti-fungal nail preparation | ASTAN, INC. (US) | 2000-12-12 | — | — | US | claimed |
| EP-1052990-A2 | CHEMICAL COMPOUNDS HAVING ION CHANNEL BLOCKING ACTIVITY FOR THE TREATMENT OF IMMUNE DYSFUNCTION | NEUROSEARCH A/S (DK) | 2000-11-22 | — | — | EP | claimed |
| EP-1028848-A1 | PREPOLYMER COMPOSITIONS COMPRISING AN ANTIMICROBIAL AGENT | MedLogic Global Corporation (US) | 2000-08-23 | — | — | EP | claimed |
| WO-2000028821-A1 | THERAPEUTIC ANTI-FUNGAL NAIL PREPARATION | ASTAN, INC. (US) | 2000-05-25 | — | — | WO | claimed |
| WO-1999025347-A2 | CHEMICAL COMPOUNDS HAVING ION CHANNEL BLOCKING ACTIVITY FOR THE TREATMENT OF IMMUNE DYSFUNCTION | NEUROSEARCH A/S (DK) | 1999-05-27 | — | — | WO | claimed |
| WO-1999022934-A1 | PREPOLYMER COMPOSITIONS COMPRISING AN ANTIMICROBIAL AGENT | MEDLOGIC GLOBAL CORPORATION (US) | 1999-05-14 | — | — | WO | claimed |
| US-5622712-A | CONSISTS OF A DRUG AND A QUATERNARY AMMONIUM SALT COMPOUND AS A LIPID COMPONENT | SYNTEX (U.S.A.) INC. (US) | 1997-04-22 | — | — | US | claimed |
| EP-0187702-B1 | N-(OMEGA,OMEGA-1-DIALKOXY)- AND N-(OMEGA,OMEGA-1-DIALKENOXY)-ALK-1-YL-N,N,N-TRISUBSTITUTED AMMONIUM SURFACTANTS, THEIR PREPARATION AND PHARMACEUTICAL FORMULATIONS CONTAINING THEM | SYNTEX (U.S.A.) INC. (US) | 1990-03-14 | — | — | EP | claimed |
| EP-0187702-A1 | N-(omega,omega-1-dialkoxy)- and N-(omega,omega-1-dialkenoxy)-alk-1-yl-N,N,N-trisubstituted ammonium surfactants, their preparation and pharmaceutical formulations containing them | SYNTEX (U.S.A.) INC. (US) | 1986-07-16 | — | — | EP | claimed |