Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 7/20 | 0.48 |
| ▸ | AURKA | O14965 | 3/20 | 0.48 |
| ▸ | ALK | Q9UM73 | 11/20 | 0.41 |
| ▸ | INSR | P06213 | 10/20 | 0.41 |
| ▸ | ABL1 | P00519 | 1/20 | 0.40 |
| ▸ | BCR | P11274 | 1/20 | 0.40 |
| ▸ | KIT | P10721 | 4/20 | 0.40 |
| ▸ | FLT3 | P36888 | 3/20 | 0.40 |
| ▸ | PLK4 | O00444 | 1/20 | 0.38 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.38 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.38 |
| ▸ | PRKCG | P05129 | 1/20 | 0.38 |
| ▸ | ROS1 | P08922 | 1/20 | 0.38 |
| ▸ | FER | P16591 | 1/20 | 0.38 |
| ▸ | LTK | P29376 | 1/20 | 0.38 |
| ▸ | WEE1 | P30291 | 1/20 | 0.38 |
| ▸ | FRK | P42685 | 1/20 | 0.38 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.38 |
| ▸ | MST1R | Q04912 | 1/20 | 0.38 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL650431 | 0.89 | AURKA (0.54) | IGF1RAURKAALKINSRABL1 | |
| SCHEMBL2907317 | 0.88 | AURKA (0.48) | IGF1RAURKAALKINSRABL1 | |
| SCHEMBL2914823 | 0.87 | AURKA (0.35) | AURKA | |
| SCHEMBL2910310 | 0.82 | IGF1R (0.55) | IGF1RAURKAALKINSRABL1 | |
| SCHEMBL1779562 | 0.78 | AURKA (0.57) | IGF1RAURKAALKINSRABL1 | |
| SCHEMBL2912187 | 0.78 | RXFP1 (0.41) | AURKA | |
| SCHEMBL2912226 | 0.78 | PTGES (0.35) | IGF1R | |
| SCHEMBL652262 | 0.77 | AURKA (0.54) | IGF1RAURKAALKINSRABL1 | |
| SCHEMBL15362116 | 0.76 | IGF1R (0.49) | IGF1RAURKAALKINSRABL1 | |
| SCHEMBL653338 | 0.76 | AURKA (0.65) | AURKAABL1BCRKITFLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2051981-B1 | 1H-FURO[3,2-C] PYRAZOLE COMPOUNDS USEFUL AS KINASE INHIBITORS | NERVIANO MEDICAL SCIENCES SRL (IT) | 2010-08-25 | — | — | EP | claimed |