Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 10/20 | 0.54 |
| ▸ | INSR | P06213 | 11/20 | 0.44 |
| ▸ | ALK | Q9UM73 | 11/20 | 0.44 |
| ▸ | IGF1R | P08069 | 8/20 | 0.44 |
| ▸ | ABL1 | P00519 | 2/20 | 0.43 |
| ▸ | BCR | P11274 | 1/20 | 0.43 |
| ▸ | KIT | P10721 | 2/20 | 0.41 |
| ▸ | FLT3 | P36888 | 2/20 | 0.41 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.39 |
| ▸ | PLK4 | O00444 | 1/20 | 0.39 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.39 |
| ▸ | JAK2 | O60674 | 1/20 | 0.39 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.39 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.39 |
| ▸ | PRKCG | P05129 | 1/20 | 0.39 |
| ▸ | LCK | P06239 | 1/20 | 0.39 |
| ▸ | FYN | P06241 | 1/20 | 0.39 |
| ▸ | CSF1R | P07333 | 1/20 | 0.39 |
| ▸ | LYN | P07948 | 1/20 | 0.39 |
| ▸ | RET | P07949 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2907317 | 0.89 | AURKA (0.48) | AURKAINSRALKIGF1RABL1 | |
| SCHEMBL2910788 | 0.89 | INSR (0.48) | AURKAINSRALKIGF1RABL1 | |
| SCHEMBL654837 | 0.88 | AURKA (0.42) | AURKAABL1BCRKIT | |
| SCHEMBL650431 | 0.88 | AURKA (0.54) | AURKAINSRALKIGF1RABL1 | |
| SCHEMBL4078547 | 0.87 | AURKA (0.46) | AURKAABL1BCR | |
| SCHEMBL653338 | 0.85 | AURKA (0.65) | AURKAABL1BCRKITFLT3 | |
| SCHEMBL4086497 | 0.84 | AURKA (0.71) | AURKAABL1BCRKITFLT3 | |
| SCHEMBL653322 | 0.77 | ALK (0.54) | AURKAINSRALKIGF1RABL1 | |
| SCHEMBL2909200 | 0.77 | IGF1R (0.48) | AURKAINSRALKIGF1RABL1 | |
| SCHEMBL652354 | 0.77 | AURKA (0.41) | AURKAABL1BCRKIT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8119641-B2 | 1H-furo[3,2-C]pyrazole compounds useful as kinase inhibitors | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2012-02-21 | — | — | US | claimed |
| US-8119641-B2 | 1H-furo[3,2-C]pyrazole compounds useful as kinase inhibitors | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2012-02-21 | — | — | US | disclosed |