SCHEMBL650431

SCHEMBL650431

CN1CCN(c2ccc(C(=O)Nc3n[nH]c4cc(C(=O)NC(C)(C)c5ccccc5)oc34)c(NC(=O)c3ccc[nH]3)c2)CC1

nearest known ligand 0.54

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
AURKA O14965 6/20 0.54
IGF1R P08069 7/20 0.50
ABL1 P00519 1/20 0.45
BCR P11274 1/20 0.45
INSR P06213 9/20 0.44
ALK Q9UM73 9/20 0.44
KIT P10721 3/20 0.40
FLT3 P36888 3/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2909200 0.89 IGF1R (0.48) AURKAIGF1RABL1BCRINSR
SCHEMBL2910310 0.89 IGF1R (0.55) AURKAIGF1RABL1INSRALK
SCHEMBL652262 0.88 AURKA (0.54) AURKAIGF1RABL1BCRINSR
SCHEMBL653338 0.86 AURKA (0.65) AURKAABL1BCRKITFLT3
SCHEMBL651124 0.86 AURKA (0.40) AURKAABL1BCR
SCHEMBL4086497 0.85 AURKA (0.71) AURKAABL1BCRKITFLT3
SCHEMBL1779562 0.83 AURKA (0.57) AURKAIGF1RABL1BCRINSR
SCHEMBL4081182 0.78 AURKA (0.61) AURKAABL1BCRINSRKIT
SCHEMBL4081915 0.78 AURKA (0.62) AURKAIGF1RABL1BCRINSR
SCHEMBL653322 0.77 ALK (0.54) AURKAIGF1RABL1INSRALK

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-106353692-B Monitoring system for detecting the presence of electrical leakage and/or short circuit condition of relay in electrical system 株式会社电装 2020-04-21 CN disclosed
US-10180459-B2 Monitoring system for detecting occurrence of leakage current and/or relay short-circuit condition in an electrical system DENSO CORPORATION (JP) 2019-01-15 US disclosed
CN-106353692-A MONITORING SYSTEM FOR DETECTING OCCURRENCE OF LEAKAGE CURRENT AND/OR RELAY SHORT-CIRCUIT CONDITION IN AN ELECTRICAL SYSTEM 株式会社电装 2017-01-25 CN disclosed
US-20170016959-A1 MONITORING SYSTEM FOR DETECTING OCCURRENCE OF LEAKAGE CURRENT AND/OR RELAY SHORT-CIRCUIT CONDITION IN AN ELECTRICAL SYSTEM DENSO CORPORATION (JP) 2017-01-19 US disclosed
US-20160284565-A1 SEMICONDUCTOR DEVICE MANUFACTURING METHOD RENESAS ELECTRONICS CORPORATION (JP) 2016-09-29 US disclosed
US-8939950-B2 Supply chain method and apparatus for sealing and unsealing a vacuum draw path MEDINDICA-PAK, INC (US) 2015-01-27 US disclosed
US-8905984-B2 Supply chain method and apparatus for sealing and unsealing a vacuum draw path MEDINDICA-PAK, INC. (US) 2014-12-09 US disclosed
US-8894625-B2 Disposal chain supply systems method and apparatus MEDINDICA-PAK, INC. (US) 2014-11-25 US disclosed
US-8888753-B2 Disposal chain supply systems method and apparatus MEDINDICA-PAK, INC. (US) 2014-11-18 US disclosed
US-20120109081-A1 Disposal Chain Supply Systems Method And Apparatus MEDINDICA-PAK, INC. 2012-05-03 US disclosed
US-8118795-B2 Disposal chain supply systems method and apparatus MEDINDICA-PAK, INC (US) 2012-02-21 US disclosed
US-20110118682-A1 Supply chain method and apparatus for sealing and unsealing a vacuum draw path MEDINDICA-PAK, INC. 2011-05-19 US disclosed
US-20110118681-A1 Supply chain method and apparatus for sealing and unsealing a vacuum draw path Medlndica-Pak, Inc. 2011-05-19 US disclosed
US-7854729-B2 Supply chain method and apparatus for sealing and unsealing a vacuum draw path MEDINDICA-PAK, INC. (US) 2010-12-21 US disclosed
US-20090239924-A1 1H-FURO[3,2-C]PYRAZOLE COMPOUNDS USEFUL AS KINASE INHIBITORS NERVIANO MEDICAL SCIENCES S.R.L. (IT) 2009-09-24 US disclosed
US-20070244451-A1 Supply chain method and apparatus for sealing and unsealing a vacuum draw path MEDINDICA-PAK, INC. 2007-10-18 US disclosed
WO-2006102205-A2 DISPOSAL CHAIN SUPPLY SYSTEMS METHOD AND APPARATUS MEDINDICA-PAK, INC. (US) 2006-09-28 WO disclosed
US-20060217674-A1 Disposal chain supply systems method and apparatus MEDINDICA-PAK, INC. 2006-09-28 US disclosed
JP-2001068077-A BATTERY PACK TOSHIBA BATTERY CO LTD 2001-03-16 JP disclosed
CN-1183643-A Semiconductor device and lead of frame used therefor NEC CORP (JP) 1998-06-03 CN disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090239924-A1 1H-FURO[3,2-C]PYRAZOLE COMPOUNDS USEFUL AS KINASE INHIBITORS IGF1R, CDK1, CDK15 AURKA 5/4885IGF1R 1/4885ABL1 428/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.