Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.54 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.54 |
| ▸ | HPGD | P15428 | 2/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.52 |
| ▸ | TSHR | P16473 | 3/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.52 |
| ▸ | GAA | P10253 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 3/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | ATM | Q13315 | 1/20 | 0.45 |
| ▸ | PRKDC | P78527 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.43 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2902911 | 0.85 | TDP1 (0.45) | ALDH1A1KDM4ETDP1NPSR1HPGD | |
| SCHEMBL981752 | 0.78 | HTT (0.74) | ALDH1A1KDM4ENPSR1HPGDHSD17B10 | |
| SCHEMBL2927049 | 0.78 | HPGD (0.67) | ALDH1A1KDM4ETDP1NPSR1HPGD | |
| SCHEMBL3059830 | 0.76 | P2RY12 (0.59) | ALDH1A1TDP1HPGDTSHRLMNA | |
| SCHEMBL29521457 | 0.76 | P2RY12 (0.59) | ALDH1A1TDP1HPGDTSHRLMNA | |
| SCHEMBL2921143 | 0.76 | P2RY12 (0.59) | ALDH1A1TDP1HPGDTSHRLMNA | |
| SCHEMBL20055871 | 0.76 | ALDH1A1 (0.47) | ALDH1A1KDM4ETDP1NPSR1HPGD | |
| SCHEMBL16834258 | 0.76 | ALDH1A1 (0.47) | ALDH1A1KDM4ETDP1NPSR1HPGD | |
| SCHEMBL1271826 | 0.76 | MAPT (0.67) | ALDH1A1KDM4ETDP1NPSR1HPGD | |
| SCHEMBL29521263 | 0.75 | P2RY12 (0.58) | ALDH1A1TDP1HPGDTSHRLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2217606-A1 | SOLUBILIZED THIAZOLOPYRIDINES | Sirtris Pharmaceuticals, Inc. (US) | 2010-08-18 | — | — | EP | disclosed |
| WO-2009061453-A1 | SOLUBILIZED THIAZOLOPYRIDINES | SIRTRIS PHARMACEUTICALS, INC. (US) | 2009-05-14 | — | — | WO | disclosed |