Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.42 |
| ▸ | PDE4A | P27815 | 1/20 | 0.42 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.42 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.42 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 2/20 | 0.41 |
| ▸ | ATP4A | P20648 | 1/20 | 0.41 |
| ▸ | ATP4B | P51164 | 1/20 | 0.41 |
| ▸ | KDR | P35968 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2916664 | 0.90 | LMNA (0.49) | LMNAKDM4EALDH1A1SMN1; SMN2TDP1 | |
| SCHEMBL2914597 | 0.87 | LMNA (0.50) | LMNAKDM4EALDH1A1SMN1; SMN2TDP1 | |
| SCHEMBL1496351 | 0.85 | LMNA (0.52) | LMNAKDM4EALDH1A1SMN1; SMN2TDP1 | |
| SCHEMBL2908904 | 0.83 | KDR (0.46) | LMNAKDM4EALDH1A1SMN1; SMN2HTT | |
| SCHEMBL1496357 | 0.81 | MAPT (0.48) | LMNAKDM4EALDH1A1SMN1; SMN2HTT | |
| SCHEMBL1496291 | 0.81 | KDM4E (0.47) | LMNAKDM4EALDH1A1SMN1; SMN2HTT | |
| SCHEMBL1496285 | 0.79 | KDM4E (0.44) | LMNAKDM4EALDH1A1SMN1; SMN2HTT | |
| SCHEMBL2916686 | 0.78 | NPC1 (0.54) | LMNAKDM4EALDH1A1SMN1; SMN2HTT | |
| SCHEMBL1496254 | 0.78 | KDR (0.48) | LMNAKDM4EALDH1A1SMN1; SMN2HTT | |
| SCHEMBL4015846 | 0.77 | KDR (0.53) | LMNAKDM4EALDH1A1SMN1; SMN2TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1854787-B1 | NOVEL CYCLIC COMPOUND HAVING QUINOLYLALKYLTHIO GROUP | SANTEN PHARMACEUTICAL CO LTD (JP) | 2010-09-01 | — | — | EP | claimed |