Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.54 |
| ▸ | CASP3 | P42574 | 1/20 | 0.54 |
| ▸ | RAB9A | P51151 | 1/20 | 0.54 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.54 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.54 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | KDR | P35968 | 3/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | EGLN1 | Q9GZT9 | 2/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2916924 | 0.84 | KDR (0.53) | NPC1CASP3RAB9ASENP8SENP7 | |
| SCHEMBL2908962 | 0.84 | KDR (0.67) | NPC1CASP3RAB9ASENP8SENP7 | |
| SCHEMBL2916664 | 0.81 | LMNA (0.49) | RAB9AKMT2AMEN1ALDH1A1KDM4E | |
| SCHEMBL1496388 | 0.81 | SMN1; SMN2 (0.51) | NPC1RAB9AKMT2AMEN1ALDH1A1 | |
| SCHEMBL4015002 | 0.81 | KDR (0.71) | NPC1RAB9AKMT2AMEN1ALDH1A1 | |
| SCHEMBL1496368 | 0.80 | KDR (0.51) | NPC1CASP3RAB9ASENP8SENP7 | |
| SCHEMBL1496291 | 0.80 | KDM4E (0.47) | NPC1KMT2AMEN1ALDH1A1L3MBTL1 | |
| SCHEMBL4020286 | 0.80 | KDR (0.58) | KMT2AMEN1ALDH1A1L3MBTL1KDM4E | |
| SCHEMBL2908904 | 0.80 | KDR (0.46) | NPC1CASP3RAB9ASENP8SENP7 | |
| SCHEMBL1939965 | 0.80 | KDR (0.50) | NPC1KMT2AMEN1ALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1854787-B1 | NOVEL CYCLIC COMPOUND HAVING QUINOLYLALKYLTHIO GROUP | SANTEN PHARMACEUTICAL CO LTD (JP) | 2010-09-01 | — | — | EP | claimed |