⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5842293 | 0.72 | — | — | |
| SCHEMBL11715864 | 0.72 | — | — | |
| SCHEMBL6571045 | 0.70 | — | — | |
| SCHEMBL28416771 | 0.65 | POLB (0.32) | — | |
| SCHEMBL11753834 | 0.63 | ALDH1A1 (0.40) | — | |
| SCHEMBL15918875 | 0.63 | — | — | |
| SCHEMBL10568754 | 0.61 | ALDH1A1 (0.54) | — | |
| SCHEMBL9350619 | 0.61 | ALDH1A1 (0.54) | — | |
| SCHEMBL432048 | 0.58 | — | — | |
| SCHEMBL6058527 | 0.56 | KMT2A (0.30) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11851418-B2 | Heteroaromatic carboxamide derivatives as plasma kallikrein inhibitors | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2023-12-26 | — | — | US | disclosed |
| CN-112080011-B | Dendritic macromolecule quaternary ammonium salt compound and preparation method and application thereof | 惠州卫生职业技术学院 | 2022-08-16 | — | — | CN | disclosed |
| US-20210276976-A1 | HETEROAROMATIC CARBOXAMIDE DERIVATIVES AS PLASMA KALLIKREIN INHIBITORS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2021-09-09 | — | — | US | disclosed |
| EP-1879884-B1 | AZOLE-BASED PHOSPHODIESTERASE INHIBITORS | RANBAXY LAB LTD (IN) | 2010-08-25 | — | — | EP | disclosed |
| EP-1879884-A1 | AZOLE-BASED PHOSPHODIESTERASE INHIBITORS | Ranbaxy Laboratories Limited (IN) | 2008-01-23 | — | — | EP | disclosed |
| WO-2006117653-A1 | AZOLE-BASED PHOSPHODIESTERASE INHIBITORS | RANBAXY LABORATORIES LIMITED (IN) | 2006-11-09 | — | — | WO | disclosed |
| EP-1300406-B1 | Method for producing pyridine compound | EISAI CO LTD (JP) | 2004-10-06 | — | — | EP | disclosed |
| US-6555559-B1 | Prostaglandin I2 (PGI2); use as an anti-Helicobacter agent, a platelet function potentiating agent or a cervical ripening agent; side effect reduction | TORAY INDUSTRIES, INC. (JP) | 2003-04-29 | — | — | US | disclosed |
| EP-0724582-B1 | PREPARATION OF OMEPRAZOLE AND LANSOPRAZOLE AND INTERMEDIATES USEFUL THEREIN | TORCAN CHEMICAL LTD (CA) | 2001-10-10 | — | — | EP | disclosed |
| EP-1044972-A1 | 5,6,7-TRINOR-4,8-INTER-m-PHENYLENE PGI2 DERIVATIVE AND DRUGS CONTAINING THE SAME | TORAY INDUSTRIES, INC. (JP) | 2000-10-18 | — | — | EP | disclosed |
| US-5502195-A | Sulfoxide-carboxylate intermediates of omeprazole and lansoprazole | TORCAN CHEMICAL LTD. (CA) | 1996-03-26 | — | — | US | disclosed |
| US-5470983-A | Preparation of omeprazole and lansoprazole, and intermediates useful therein | TORCAN CHEMICAL LTD. (CA) | 1995-11-28 | — | — | US | disclosed |
| US-5374730-A | Preparation of omeprazole and lansoprazole | TORCAN CHEMICAL LTD. (CA) | 1994-12-20 | — | — | US | disclosed |
| EP-0389162-B1 | 2,5,6,7-Tetranor-4,8-inter-m-phenylene PGI2 derivatives | TORAY INDUSTRIES (JP) | 1993-12-08 | — | — | EP | disclosed |
| US-5086071-A | Improved chemical stability and ppotent in vivo | TORAY INDUSTRIES, INC. (JP) | 1992-02-04 | — | — | US | disclosed |
| EP-0389162-A1 | 2,5,6,7-Tetranor-4,8-inter-m-phenylene PGI2 derivatives | TORAY INDUSTRIES, INC. (JP) | 1990-09-26 | — | — | EP | disclosed |