Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 11/20 | 0.57 |
| ▸ | ALK | Q9UM73 | 8/20 | 0.55 |
| ▸ | INSR | P06213 | 3/20 | 0.53 |
| ▸ | IGF1R | P08069 | 3/20 | 0.53 |
| ▸ | MAPK7 | Q13164 | 2/20 | 0.52 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.52 |
| ▸ | JAK2 | O60674 | 1/20 | 0.52 |
| ▸ | SRC | P12931 | 1/20 | 0.52 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29097557 | 0.88 | EGFR (0.54) | EGFRALKINSRIGF1RJAK2 | |
| SCHEMBL29097718 | 0.87 | BRD4 (0.59) | EGFRALKJAK2SRCTNK2 | |
| SCHEMBL18491223 | 0.75 | EGFR (0.73) | EGFRALKINSRIGF1RJAK2 | |
| SCHEMBL29097550 | 0.75 | BRD4 (0.56) | EGFRALKJAK2SRCTNK2 | |
| SCHEMBL29097714 | 0.74 | ABL1 (0.39) | — | |
| SCHEMBL30621965 | 0.74 | ABL1 (0.39) | — | |
| SCHEMBL24255898 | 0.73 | EGFR (0.80) | EGFRALKINSRIGF1RLRRK2 | |
| SCHEMBL30123962 | 0.73 | EGFR (0.77) | EGFRALKINSRIGF1RMAPK7 | |
| SCHEMBL24256003 | 0.73 | EGFR (0.69) | EGFRALKINSRIGF1RJAK2 | |
| SCHEMBL26451583 | 0.73 | EGFR (0.77) | EGFRALKINSRIGF1RMAPK7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2025011447-A1 | PYRIMIDINAMINE NUAK INHIBITOR, AND PREPARATION METHOD THEREFOR AND USE THEREOF | 特科罗生物科技(成都)有限公司 | 2025-01-16 | — | — | WO | disclosed |
| CN-116903592-A | Pyrimidine amine NUAK inhibitor and preparation method and application thereof | 特科罗生物科技(成都)有限公司 | 2023-10-20 | — | — | CN | disclosed |