Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 10/20 | 0.56 |
| ▸ | JAK2 | O60674 | 4/20 | 0.51 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.49 |
| ▸ | TNK2 | Q07912 | 3/20 | 0.47 |
| ▸ | FGFR4 | P22455 | 2/20 | 0.47 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.47 |
| ▸ | ABL1 | P00519 | 1/20 | 0.47 |
| ▸ | LCK | P06239 | 1/20 | 0.47 |
| ▸ | ROS1 | P08922 | 1/20 | 0.47 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.47 |
| ▸ | SRC | P12931 | 1/20 | 0.47 |
| ▸ | TYK2 | P29597 | 1/20 | 0.47 |
| ▸ | AXL | P30530 | 1/20 | 0.47 |
| ▸ | NEK2 | P51955 | 1/20 | 0.47 |
| ▸ | JAK1 | P23458 | 1/20 | 0.46 |
| ▸ | BRD2 | P25440 | 1/20 | 0.46 |
| ▸ | JAK3 | P52333 | 1/20 | 0.46 |
| ▸ | BRD3 | Q15059 | 1/20 | 0.46 |
| ▸ | BRDT | Q58F21 | 1/20 | 0.46 |
| ▸ | CCNK | O75909 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29097557 | 0.88 | EGFR (0.54) | JAK2ALKTNK2SRCEGFR | |
| SCHEMBL29097718 | 0.86 | BRD4 (0.59) | BRD4JAK2ALKTNK2FGFR4 | |
| SCHEMBL30621972 | 0.83 | ALK (0.57) | BRD4JAK2ALKTNK2CHEK1 | |
| SCHEMBL29097716 | 0.83 | ALK (0.57) | BRD4JAK2ALKTNK2CHEK1 | |
| SCHEMBL31318206 | 0.82 | MAP3K7 (0.47) | BRD4ALKFGFR1SRCCCNK | |
| SCHEMBL29097572 | 0.81 | MAP3K7 (0.47) | BRD4JAK2ALKTNK2CHEK1 | |
| SCHEMBL29097715 | 0.79 | SLC2A1 (0.51) | BRD4ALKFGFR1SRCCCNK | |
| SCHEMBL29097706 | 0.79 | SCN9A (0.34) | BRD4 | |
| SCHEMBL30621970 | 0.79 | SCN9A (0.34) | BRD4 | |
| SCHEMBL30621971 | 0.78 | JAK2 (0.53) | BRD4JAK2FGFR4JAK1BRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4745132-A1 | PYRIMIDINAMINE NUAK INHIBITOR, AND PREPARATION METHOD THEREFOR AND USE THEREOF | Technoderma Medicines Inc. (CN) | 2026-05-20 | — | — | EP | disclosed |
| WO-2025011447-A1 | PYRIMIDINAMINE NUAK INHIBITOR, AND PREPARATION METHOD THEREFOR AND USE THEREOF | 特科罗生物科技(成都)有限公司 | 2025-01-16 | — | — | WO | disclosed |
| CN-116903592-A | Pyrimidine amine NUAK inhibitor and preparation method and application thereof | 特科罗生物科技(成都)有限公司 | 2023-10-20 | — | — | CN | disclosed |