Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 11/20 | 0.59 |
| ▸ | JAK2 | O60674 | 4/20 | 0.53 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.52 |
| ▸ | FGFR4 | P22455 | 2/20 | 0.50 |
| ▸ | AXL | P30530 | 1/20 | 0.49 |
| ▸ | NEK2 | P51955 | 1/20 | 0.49 |
| ▸ | JAK1 | P23458 | 1/20 | 0.49 |
| ▸ | BRD2 | P25440 | 1/20 | 0.49 |
| ▸ | JAK3 | P52333 | 1/20 | 0.49 |
| ▸ | BRD3 | Q15059 | 1/20 | 0.49 |
| ▸ | BRDT | Q58F21 | 1/20 | 0.49 |
| ▸ | CCNK | O75909 | 1/20 | 0.49 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.49 |
| ▸ | CDK2 | P24941 | 1/20 | 0.49 |
| ▸ | CCND3 | P30281 | 1/20 | 0.49 |
| ▸ | CDK9 | P50750 | 1/20 | 0.49 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.49 |
| ▸ | EGFR | P00533 | 1/20 | 0.48 |
| ▸ | TNK2 | Q07912 | 3/20 | 0.48 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29097552 | 0.87 | EGFR (0.57) | JAK2ALKEGFRTNK2SRC | |
| SCHEMBL29097550 | 0.86 | BRD4 (0.56) | BRD4JAK2ALKFGFR4AXL | |
| SCHEMBL29097558 | 0.83 | JAK2 (0.53) | BRD4JAK2FGFR4JAK1BRD2 | |
| SCHEMBL30621971 | 0.83 | JAK2 (0.53) | BRD4JAK2FGFR4JAK1BRD2 | |
| SCHEMBL29097711 | 0.80 | ALK (0.49) | BRD4JAK2ALKCCNKCCNA2 | |
| SCHEMBL29097714 | 0.79 | ABL1 (0.39) | BRD4ABL1 | |
| SCHEMBL30621965 | 0.79 | ABL1 (0.39) | BRD4ABL1 | |
| SCHEMBL1885643 | 0.74 | BRD4 (0.70) | BRD4JAK2ALKAXLNEK2 | |
| SCHEMBL18757714 | 0.74 | BRD4 (1.00) | BRD4JAK2ALKJAK1BRD2 | |
| SCHEMBL1606982 | 0.74 | BRD4 (0.69) | BRD4ALKAXLNEK2CCNK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4745132-A1 | PYRIMIDINAMINE NUAK INHIBITOR, AND PREPARATION METHOD THEREFOR AND USE THEREOF | Technoderma Medicines Inc. (CN) | 2026-05-20 | — | — | EP | disclosed |
| WO-2025011447-A1 | PYRIMIDINAMINE NUAK INHIBITOR, AND PREPARATION METHOD THEREFOR AND USE THEREOF | 特科罗生物科技(成都)有限公司 | 2025-01-16 | — | — | WO | disclosed |
| CN-116903592-A | Pyrimidine amine NUAK inhibitor and preparation method and application thereof | 特科罗生物科技(成都)有限公司 | 2023-10-20 | — | — | CN | disclosed |