SCHEMBL290976

SCHEMBL290976

O=C1NC(=O)C(Cc2ccc3oc(-c4ccc5ccccc5c4)nc3c2)S1

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
UTRN P46939 8/20 0.48
CYP1A2 P05177 1/20 0.48
AHR P35869 1/20 0.48
HDAC6 Q9UBN7 1/20 0.48
MAPT P10636 6/20 0.46
THRB P10828 2/20 0.46
ESR1 P03372 2/20 0.45
ALDH1A1 P00352 2/20 0.45
KDM4E B2RXH2 1/20 0.45
MEN1 O00255 1/20 0.45
NPC1 O15118 1/20 0.45
HPGD P15428 1/20 0.45
RAB9A P51151 1/20 0.45
KMT2A Q03164 1/20 0.45
SMN1; SMN2 Q16637 1/20 0.45
ESR2 Q92731 1/20 0.44
PPARG P37231 2/20 0.43
FFAR1 O14842 1/20 0.43
TP53 P04637 2/20 0.43
AKT1 P31749 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29702319 1.00 UTRN (0.48) UTRNCYP1A2AHRHDAC6MAPT
SCHEMBL9558560 0.89 PPARG (0.49) HDAC6MAPTALDH1A1KDM4ENPC1
SCHEMBL377496 0.84 FFAR1 (0.43) MAPTALDH1A1SMN1; SMN2PPARGFFAR1
SCHEMBL9830775 0.81 PPARG (0.43) HDAC6MAPTALDH1A1KDM4EPPARG
SCHEMBL30853454 0.80 UTRN (0.46) UTRNCYP1A2AHRHDAC6MAPT
SCHEMBL13846702 0.80 PPARG (0.59) MAPTALDH1A1PPARGFFAR1NPSR1
SCHEMBL9833514 0.79 MAOA (0.43) MAPTESR1ALDH1A1KDM4EMEN1
SCHEMBL9830580 0.79 MAOB (0.55) CYP1A2HDAC6MAPTALDH1A1KDM4E
SCHEMBL9831485 0.77 PPARG (0.52) MAPTALDH1A1PPARGFFAR1AKT1
SCHEMBL9435871 0.76 PPARG (0.46) MAPTALDH1A1PPARGFFAR1NPSR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 352 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1931350-B2 ADMINISTRATION OF DIPEPTIDYL PEPTIDASE INHIBITORS TAKEDA PHARMACEUTICALS CO (JP) 2021-08-04 EP claimed
EP-1942898-B2 DIPEPTIDYL PEPTIDASE INHIBITORS FOR TREATING DIABETES TAKEDA PHARMACEUTICAL (JP) 2014-05-14 EP claimed
EP-1931350-B1 ADMINISTRATION OF DIPEPTIDYL PEPTIDASE INHIBITORS TAKEDA PHARMACEUTICAL (JP) 2013-11-20 EP claimed
EP-1942898-B1 DIPEPTIDYL PEPTIDASE INHIBITORS FOR TREATING DIABETES TAKEDA PHARMACEUTICAL (JP) 2011-11-09 EP claimed
US-20110212982-A1 Administration of Dipeptidyl Peptidase Inhibitors TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2011-09-01 US claimed
US-20110192748-A1 Administration of Dipeptidyl Peptidase Inhibitors TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2011-08-11 US claimed
EP-1942898-A1 DIPEPTIDYL PEPTIDASE INHIBITORS FOR TREATING DIABETES Takeda Pharmaceutical Company Limited (JP) 2008-07-16 EP claimed
EP-1931350-A2 ADMINISTRATION OF DIPEPTIDYL PEPTIDASE INHIBITORS Takeda Pharmaceutical Company Limited (JP) 2008-06-18 EP claimed
WO-2007033265-A1 DIPEPTIDYL PEPTIDASE INHIBITORS FOR TREATING DIABETIS TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2007-03-22 WO claimed
WO-2007033266-A2 DIPEPTIDYL PEPTIDASE INHIBITORS FOR TREATING DIABETIS TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2007-03-22 WO claimed
WO-2007033350-A1 DIPEPTIDYL PEPTIDASE INHIBITORS FOR TREATING DIABETES TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2007-03-22 WO claimed
US-20070060529-A1 ADMINISTRATION OF DIPEPTIDYL PEPTIDASE INHIBITORS DEVELOPMENT PARTNERS, LLC 2007-03-15 US claimed
US-20070060530-A1 ADMINISTRATION OF DIPEPTIDYL PEPTIDASE INHIBITORS TAKEDA SAN DIEGO, INC. 2007-03-15 US claimed
WO-2006034435-A2 METHODS AND COMPOSITIONS FOR TREATING GLUCOSE-ASSOCIATED CONDITIONS, METABOLIC SYNDROME, DYSLIPIDEMIAS AND OTHER CONDITIONS POINT THERAPEUTICS, INC. (US) 2006-03-30 WO claimed
US-12209144-B2 Cyclic peptides as proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors for the treatment of metabolic disorders NOVARTIS AG (CH) 2025-01-28 US disclosed
WO-2024055932-A1 AZACYCLIC COMPOUND, PHARMACEUTICAL COMPOSITION THEREOF, AND USE THEREOF FOR PREVENTING AND/OR TREATING DISEASE 亚宝药业集团股份有限公司 2024-03-21 WO disclosed
US-20240036046-A1 CANCER EXAMINATION METHOD AND CANCER TREATMENT AGENT IMAMITSUKAI MEDICAL CORPORATION (JP) 2024-02-01 US disclosed
WO-2001052825-A2 COMBINATIONS COMPRISING DIPEPTIDYLPEPTIDASE-IV INHIBITORS AND ANTIDIABETIC AGENTS NOVARTIS AG (CH) 2001-07-26 WO disclosed
WO-2001047514-A1 USE OF HYPOGLYCEMIC AGENT FOR TREATING IMPAIRED GLUCOSE METABOLISM NOVARTIS AG (CH) 2001-07-05 WO disclosed
WO-2001026639-A2 PHARMACEUTICAL COMPOSITION OF ATEGLINIDE AND ANOTHER ANTIDIABETICAGENT NOVARTIS AG (CH) 2001-04-19 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110192748-A1 Administration of Dipeptidyl Peptidase Inhibitors DPP4, DPP7, DPP3 UTRN 698/4885CYP1A2 1546/4885AHR 2407/4885
US-20070060530-A1 ADMINISTRATION OF DIPEPTIDYL PEPTIDASE INHIBITORS DPP4, DPP7, DPP3 UTRN 698/4885CYP1A2 1546/4885AHR 2407/4885
US-20110212982-A1 Administration of Dipeptidyl Peptidase Inhibitors DPP4, DPP7, DPP3 UTRN 781/4885CYP1A2 1509/4885AHR 2660/4885
US-12209144-B2 Cyclic peptides as proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors for the treatment of metabolic disorders PCSK9, PCSK7, PCSK6 UTRN 2474/4885CYP1A2 3827/4885AHR 3509/4885
US-20070060529-A1 ADMINISTRATION OF DIPEPTIDYL PEPTIDASE INHIBITORS DPP7, DPP4, DPP3 UTRN 697/4885CYP1A2 1370/4885AHR 2558/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.