Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 10/20 | 0.46 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.45 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.45 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | CTSD | P07339 | 1/20 | 0.43 |
| ▸ | CTSE | P14091 | 1/20 | 0.43 |
| ▸ | BACE1 | P56817 | 1/20 | 0.43 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.43 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | HCAR1 | Q9BXC0 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2586290 | 0.93 | GPR119 (0.48) | GPR119PTPN2PTPN1PTPN6ALDH1A1 | |
| SCHEMBL20046185 | 0.90 | GPR119 (0.49) | GPR119PTPN2PTPN1PTPN6ALDH1A1 | |
| SCHEMBL14635882 | 0.90 | GPR119 (0.48) | GPR119ALDH1A1MAPTL3MBTL1 | |
| SCHEMBL29945868 | 0.85 | GPR119 (0.48) | GPR119PTPN2PTPN1PTPN6ALDH1A1 | |
| SCHEMBL15950964 | 0.85 | GPR119 (0.50) | GPR119PTPN2PTPN1PTPN6ALDH1A1 | |
| SCHEMBL1582522 | 0.84 | GPR119 (0.47) | GPR119PTPN2PTPN1PTPN6ALDH1A1 | |
| SCHEMBL27459322 | 0.84 | GPR119 (0.47) | GPR119PTPN2PTPN1PTPN6ALDH1A1 | |
| SCHEMBL1557907 | 0.84 | CTSD (0.49) | GPR119PTPN2PTPN1PTPN6ALDH1A1 | |
| SCHEMBL3131511 | 0.84 | GPR119 (0.47) | GPR119PTPN2PTPN1PTPN6ALDH1A1 | |
| SCHEMBL29098496 | 0.83 | PLAT (0.42) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4146660-A1 | BIFUNCTIONAL DEGRADERS OF HEMATOPOIETIC PROGENITOR KINASE AND THERAPEUTIC USES THEREOF | Nurix Therapeutics, Inc. (US) | 2023-03-15 | — | — | EP | disclosed |
| CN-115605488-A | Bifunctional degradants of hematopoietic progenitor kinases and therapeutic uses thereof | 新锐思生物制药股份有限公司（US） | 2023-01-13 | — | — | CN | disclosed |