Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 4/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.34 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.34 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.34 |
| ▸ | TGM2 | P21980 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3987598 | 0.87 | HSD17B10 (0.48) | HSD17B10MAPTALDH1A1S1PR1CYP1A2 | |
| SCHEMBL4580793 | 0.87 | HSD17B10 (0.48) | HSD17B10MAPTALDH1A1S1PR1CYP1A2 | |
| SCHEMBL5554701 | 0.87 | HSD17B10 (0.48) | HSD17B10MAPTALDH1A1S1PR1SLC6A9 | |
| SCHEMBL5237881 | 0.85 | HSD17B10 (0.47) | HSD17B10MAPTALDH1A1S1PR1CYP1A2 | |
| SCHEMBL13210852 | 0.79 | HSD17B10 (0.41) | HSD17B10MAPTALDH1A1S1PR1SLC6A9 | |
| SCHEMBL2910415 | 0.76 | CHRM5 (0.40) | HSD17B10MAPTALDH1A1S1PR1SLC6A9 | |
| Tetraxetan SCHEMBL4293643 | 0.74 | HSD17B10 (0.61) | HSD17B10MAPTALDH1A1S1PR1CYP1A2 | |
| SCHEMBL15858187 | 0.72 | ALDH1A1 (0.52) | MAPTALDH1A1CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL173508 | 0.72 | HSD17B10 (0.64) | HSD17B10MAPTALDH1A1S1PR1CYP1A2 | |
| SCHEMBL6848102 | 0.72 | HSD17B10 (0.64) | HSD17B10MAPTALDH1A1S1PR1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1047677-B1 | Process for the preparation of derivatives of 1,4,7,10-tetraazacyclododecane-1,4-diacetic acid | BRACCO SPA (IT) | 2005-07-20 | — | — | EP | claimed |
| US-6342597-B1 | CONDENSATION REACTION TRIETHYLENETETRAMINE WITH GLYOXAL TO CYCLIZE; OXIDATION, ALKYLATION, HYDROLYSIS, QUATERNIZATION; NUCLEAR MAGNETIC RESONANCE IMAGING | DIBRA S.P.A. (IT) | 2002-01-29 | — | — | US | claimed |
| EP-1602649-B1 | Process for the preparation of monofunctionalized 1,4,7,10-tetraazacyclododecane | BRACCO SPA (IT) | 2010-08-18 | — | — | EP | disclosed |
| EP-1602649-B1 | Process for the preparation of monofunctionalized 1,4,7,10-tetraazacyclododecane | BRACCO SPA (IT) | 2010-08-18 | — | — | EP | disclosed |
| EP-1602649-A2 | 1,4,7,10-TETRAAZACYCLODODECANE-1,4-DIACETIC ACID DERIVATIVES AS CHELATING AGENTS | BRACCO S.p.A. (IT) | 2005-12-07 | — | — | EP | disclosed |
| EP-1047677-B1 | Process for the preparation of derivatives of 1,4,7,10-tetraazacyclododecane-1,4-diacetic acid | BRACCO SPA (IT) | 2005-07-20 | — | — | EP | disclosed |
| US-6342597-B1 | CONDENSATION REACTION TRIETHYLENETETRAMINE WITH GLYOXAL TO CYCLIZE; OXIDATION, ALKYLATION, HYDROLYSIS, QUATERNIZATION; NUCLEAR MAGNETIC RESONANCE IMAGING | DIBRA S.P.A. (IT) | 2002-01-29 | — | — | US | disclosed |