Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.43 |
| ▸ | AR | P10275 | 2/20 | 0.39 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.37 |
| ▸ | PNMT | P11086 | 1/20 | 0.37 |
| ▸ | S100A4 | P26447 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | KDM1A | O60341 | 2/20 | 0.34 |
| ▸ | EDNRB | P24530 | 1/20 | 0.34 |
| ▸ | EDNRA | P25101 | 1/20 | 0.34 |
| ▸ | METAP1 | P53582 | 2/20 | 0.33 |
| ▸ | PTPRC | P08575 | 1/20 | 0.33 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.33 |
| ▸ | TDP2 | O95551 | 1/20 | 0.33 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.33 |
| ▸ | PARP11 | Q9NR21 | 1/20 | 0.33 |
| ▸ | BCL2 | P10415 | 1/20 | 0.33 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30935380 | 1.00 | PBRM1 (0.43) | PBRM1ARADRA2APNMTS100A4 | |
| SCHEMBL26510292 | 0.78 | PARP10 (0.44) | ADRA2APNMTS100A4CYP1A2MAPK1 | |
| SCHEMBL4419838 | 0.74 | PBRM1 (0.50) | PBRM1ARADRA2APNMTS100A4 | |
| SCHEMBL2978084 | 0.72 | LMNA (0.67) | PBRM1ARLMNAGAAEDNRB | |
| SCHEMBL30917500 | 0.71 | CYP1A2 (0.41) | PBRM1ARADRA2APNMTS100A4 | |
| SCHEMBL30917758 | 0.71 | CYP1A2 (0.41) | PBRM1ARADRA2APNMTS100A4 | |
| SCHEMBL30917876 | 0.71 | CYP1A2 (0.41) | PBRM1ARADRA2APNMTS100A4 | |
| SCHEMBL27864834 | 0.70 | EDNRB (0.47) | PBRM1ARS100A4EDNRBEDNRA | |
| SCHEMBL30078429 | 0.69 | MAOB (0.31) | KDM1A | |
| SCHEMBL16693108 | 0.68 | DRD2 (0.41) | ADRA2APNMTLMNAKDM1ACYP19A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115611883-B | PI3K alpha inhibitor with double-ring structure, and preparation method and application thereof | 生物岛实验室 | 2025-03-28 | — | — | CN | disclosed |
| CN-115611883-A | PI3K alpha inhibitor with bicyclic structure and preparation method and application thereof | 生物岛实验室 | 2023-01-17 | — | — | CN | disclosed |